Full Product Name
CTSA Antibody
Product Synonym Names
GSL; GLB2; NGBE; PPCA; PPGB
Product Gene Name
anti-CTSA antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P10619
Species Reactivity
Human, Mouse
Specificity
The antibody detects endogenous levels of total CTSA protein.
Purity/Purification
Antigen Affinity Purification
Form/Format
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Concentration
1 mg/ml (lot specific)
Immunogen
Fusion protein of human CTSA
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-CTSA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CTSA antibody
This gene encodes a glycoprotein which associates with lysosomal enzymes beta-galactosidase and neuraminidase to form a complex of high molecular weight multimers. The formation of this complex provides a protective role for stability and activity.Deficiencies in this gene are linked to multiple forms of galactosialidosis. Alternatively spliced transcript variants encoding different isoformshave been found for this gene.
Product Categories/Family for anti-CTSA antibody
Total protein Ab
Applications Tested/Suitable for anti-CTSA antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CTSA antibody
Western Blot: 1:200-1:1000
Immunohistochemistry: 1:25-1:100
Western Blot (WB) of anti-CTSA antibody
Gel: 8%SDS-PAGE Lysate: 40 μ g Lane 1-2: Jurkat cells, mouse bladder tissue Primary antibody: 1/250 dilution Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 10 seconds
NCBI/Uniprot data below describe general gene information for CTSA. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000299.2
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NCBI GenBank Nucleotide #
NM_000308.3
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UniProt Primary Accession #
P10619
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UniProt Secondary Accession #
Q561W6; Q5JZH1; Q96KJ2; Q9BR08; Q9BW68; B2R798[Other Products]
UniProt Related Accession #
P10619[Other Products]
Molecular Weight
52,489 Da
NCBI Official Full Name
lysosomal protective protein isoform a
NCBI Official Synonym Full Names
cathepsin A
NCBI Official Symbol
CTSA??[Similar Products]
NCBI Official Synonym Symbols
GSL; GLB2; NGBE; PPCA; PPGB
??[Similar Products]
NCBI Protein Information
lysosomal protective protein
UniProt Protein Name
Lysosomal protective protein
UniProt Synonym Protein Names
Carboxypeptidase C; Carboxypeptidase L; Cathepsin A; Protective protein cathepsin A; PPCA
Protein Family
Lysosomal protective protein
UniProt Gene Name
CTSA??[Similar Products]
UniProt Synonym Gene Names
PPGB; PPCA??[Similar Products]
UniProt Entry Name
PPGB_HUMAN
UniProt Comments for CTSA
CTSA: Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins. Defects in CTSA are the cause of galactosialidosis (GSL). A lysosomal storage disease associated with a combined deficiency of beta-galactosidase and neuraminidase, secondary to a defect in cathepsin A. All patients have clinical manifestations typical of a lysosomal disorder, such as coarse facies, cherry red spots, vertebral changes, foam cells in the bone marrow, and vacuolated lymphocytes. Three phenotypic subtypes are recognized. The early infantile form is associated with fetal hydrops, edema, ascites, visceromegaly, skeletal dysplasia, and early death. The late infantile type is characterized by hepatosplenomegaly, growth retardation, cardiac involvement, and a normal or mildly affected mental state. The juvenile/***** form is characterized by myoclonus, ataxia, angiokeratoma, mental retardation, neurologic deterioration, absence of visceromegaly, and long survival. Belongs to the peptidase S10 family.
Protein type: EC 3.4.16.5; Endoplasmic reticulum; Mitochondrial; Protease
Chromosomal Location of Human Ortholog: 20q13.1
Cellular Component: endoplasmic reticulum; intracellular membrane-bound organelle; lysosomal lumen; membrane; nucleoplasm
Molecular Function: carboxypeptidase activity; enzyme activator activity; exo-alpha-sialidase activity; serine carboxypeptidase activity
Biological Process: glycosphingolipid metabolic process; intracellular protein transport; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of protein stability
Disease: Galactosialidosis
Precautions
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Disclaimer
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