Product Name
Meckel syndrome type 1 protein homolog (Mks1), Recombinant Protein
Full Product Name
Recombinant Mouse Meckel syndrome type 1 protein homolog (Mks1)
Product Gene Name
Mks1 recombinant protein
[Similar Products]
Product Synonym Gene Name
Mks1[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-561aa, full length protein
Sequence
MAEAVWSTDT GEAVYRSRDP VRNLRLRVHL QRITSSNFLH YQPAAQMGKD LIDLATFRPP QAASGHRPDE EEEEEVVIGW QEKLFSQFEV DLYQNESACQ SPLDHQYRQE ILKLENSGGR KNRRIFTYTD SDRYTDLEEY CQKITTSASE VPSFLAERMA NVRRRRQDRR GVEGSKLKSR IVTWEPSEDF IKNNHAINTP LQTMYIMADL GPYGKLGYKV HEHVLCILKV DSNGVITVKP DFTGIKGPYR IETEGEKQEH TSAWKYTIDN VSSLAQPEEE EREQRVFKDL YGRHKEYLSS LVGTDFEMIA PGALRLFVNG EVVSAQGYEY DNLYVHFFVE LPAANWSSPP FQQLSGVTQA CATKSLGMDK VAYFSFPFTF EAFFLHEDES AESLPEWPVL YCKVLSLDFW QRYRVEGYGA VVLPATPGSH TLTVSTWRPM ELGLVAELRR FFIGGSLELE DPSYVRIPGT FKGERLSRFG FRTETTGTVT FRLHCLQQSR AFMESNSLQK QMRSVLDRLE GFSQQSSTHN VLEAFRRARR RMQEARESLP QDLVSPTGTL T
3D Structure
ModBase 3D Structure for Q5SW45
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Mks1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Mks1 recombinant protein
This protein localizes to the basal body and is required for formation of the primary cilium in ciliated epithelial cells. Mutations in this gene result in Meckel syndrome type 1 and in Bardet-Biedl syndrome type 13. Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI/Uniprot data below describe general gene information for Mks1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001034773.2
[Other Products]
NCBI GenBank Nucleotide #
NM_001039684.2
[Other Products]
UniProt Primary Accession #
Q5SW45
[Other Products]
UniProt Secondary Accession #
Q3V3W3[Other Products]
UniProt Related Accession #
Q5SW45[Other Products]
Molecular Weight
64,416 Da
NCBI Official Full Name
Meckel syndrome type 1 protein homolog
NCBI Official Synonym Full Names
Meckel syndrome, type 1
NCBI Official Symbol
Mks1??[Similar Products]
NCBI Official Synonym Symbols
B8d3; avc6; AK190930
??[Similar Products]
NCBI Protein Information
Meckel syndrome type 1 protein homolog
UniProt Protein Name
Meckel syndrome type 1 protein homolog
Protein Family
Meckel syndrome type 1 protein
UniProt Gene Name
Mks1??[Similar Products]
UniProt Comments for Mks1
Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology.
Research Articles on Mks1
1. demonstrated that the MKS transition zone complex cooperates with the BBSome to mediate trafficking of specific trans-membrane receptors to the cilium
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
