Anti-GDF1 Antibody (N-Terminus) IHC-plus; GDF1; DTGA3; DORV; GDF-1; Human GDF1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Human GDF1. GDF1 antibody is predicted to not cross-react with any other members of the growth differentiation factor family.

Immunoaffinity Purified

PBS, 0.02% sodium azide

1 mg/ml (lot specific)

Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

Small volumes of anti-GDF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Family: TGF beta

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

IHC-P (5 ug/ml), WB (1 - 2 ug/ml)
Usage: GDF1 antibody can be used for detection of GDF1 by Western blot at 1-2 ug/mL.

Human, Small Intestine: Formalin-Fixed Paraffin-Embedded (FFPE)

Immunofluorescence of GDF1 in human lung tissue with GDF1 antibody at 20 ug/ml.

Western blot analysis of GDF1 in rat lung tissue lysate with GDF1 antibody at (A) 1 and (B) 2 ug/ml.

39,475 Da

growth differentiation factor 1

embryonic growth/differentiation factor 1; GDF-1

Embryonic growth/differentiation factor 1

GDF-1??[Similar Products]

GDF1_HUMAN

This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and ***** tissues. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. This protein is transcribed from a bicistronic mRNA that also encodes the longevity assurance gene. Mutations in this gene are associated with several congenital cardiovascular malformations. [provided by RefSeq, Mar 2014]

GDF1: May mediate cell differentiation events during embryonic development. Defects in GDF1 are a cause of conotruncal heart malformations (CTHM). A group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle. Defects in GDF1 are the cause of transposition of the great arteries dextro-looped type 3 (DTGA3). A congenital heart defect consisting of complete inversion of the great vessels, so that the aorta incorrectly arises from the right ventricle and the pulmonary artery incorrectly arises from the left ventricle. This creates completely separate pulmonary and systemic circulatory systems, an arrangement that is incompatible with life. The presence or absence of associated cardiac anomalies defines the clinical presentation and surgical management of patients with transposition of the great arteries. Defects in GDF1 are a cause of tetralogy of Fallot (TOF). A congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing cyanosis. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19p12

Cellular Component: extracellular space

Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: BMP signaling pathway; regulation of apoptosis; regulation of MAPKKK cascade; cell development; growth

Disease: Transposition Of The Great Arteries, Dextro-looped 3; Right Atrial Isomerism; Conotruncal Heart Malformations; Tetralogy Of Fallot

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