Human NACHT; LRR and PYD domains-containing protein 12 (NLRP12) ELISA kit; CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2; NACHT; LRR and PYD containing protein 12; NACHT; leucine rich repeat and PYD containing 12; PYRIN-containing APAF1-like protein 7; monarch 1; nucleotide-; NLR family; pyrin domain containing 12

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of NLRP12 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9334965 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the NLR family, pyrin domain containing 12 (NLRP12) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing NLRP12. The ELISA analytical biochemical technique of the MBS9334965 kit is based on NLRP12 antibody-NLRP12 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NLRP12 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NLRP12. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

120,173 Da

NLR family, pyrin domain containing 12

NACHT, LRR and PYD domains-containing protein 12; monarch 1; regulated by nitric oxide; PYRIN-containing APAF1-like protein 7; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12

NACHT, LRR and PYD domains-containing protein 12

NALP12; PYPAF7; RNO??[Similar Products]

NAL12_HUMAN

This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

NLRP12: May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK. Defects in NLRP12 are the cause of familial cold autoinflammatory syndrome type 2 (FCAS2). FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold. Belongs to the NLRP family. 5 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19q13.42

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; caspase activator activity; ATP binding

Biological Process: release of cytoplasmic sequestered NF-kappaB; caspase activation; negative regulation of cytokine secretion; negative regulation of interleukin-6 biosynthetic process; positive regulation of interleukin-1 beta secretion; negative regulation of I-kappaB kinase/NF-kappaB cascade; signal transduction; regulation of caspase activity; negative regulation of signal transduction; negative regulation of Toll signaling pathway; inhibition of NF-kappaB transcription factor; negative regulation of inflammatory response; negative regulation of protein amino acid autophosphorylation; positive regulation of MHC class I biosynthetic process; regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of interleukin-1 secretion; regulation of interleukin-18 biosynthetic process; positive regulation of inflammatory response

Disease: Familial Cold Autoinflammatory Syndrome 2

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