For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 1; NC_000001.10 (201328142..201346805, complement). Location: 1q32

E Coli

Human Cardiac Troponin T (TnT)

Greater than 90% as determined by SDS-PAGE

Sterile-filtered solution in 20mM Tris, pH 8.0, 10% glycerol. Purified by proprietary chromatographic techniques.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store at -20 degree C for longer periods of time. For long term storage, additon of 0.1% human serum albumin or bovine serum albumin is recommended. Avoid multiple freeze-thaw cycles.

Small volumes of TNNT2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Troponin T (TnT) is the tropomyosinbinding subunit of the troponin complex which is situated on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentrations. Mutations in the TNNT2 gene are associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy and hypertrophic cardiomyopathy.

Recombinant Human TnT produced in E. coli is a single, non-glycosylated polypeptide chain containing 305 amino acids (aa 1-285) with a molecular weight of 36.4 kDa. It is fused to a 20-amino acid His-tag at the N-terminus.

35,924 Da[Similar Products]

troponin T type 2 (cardiac)

troponin T, cardiac muscle; OTTHUMP00000033864; OTTHUMP00000033865; OTTHUMP00000033866; OTTHUMP00000033867; OTTHUMP00000033870; OTTHUMP00000218095; troponin T2, cardiac; cardiac muscle troponin T; cardiomyopathy, hypertrophic 2; cardiomyopathy, dilated 1D (autosomal dominant)

Troponin T, cardiac muscle

TNNT2_HUMAN

The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq]

TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the ***** heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal ***** heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing ***** heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing.

Protein type: Motor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: sarcomere; troponin complex; cytosol; striated muscle thin filament

Molecular Function: troponin C binding; structural constituent of cytoskeleton; troponin I binding; ATPase activity; actin binding; tropomyosin binding

Biological Process: atrial cardiac muscle morphogenesis; positive regulation of ATPase activity; metabolic process; regulation of muscle contraction; ventricular cardiac muscle morphogenesis; sarcomere organization; response to calcium ion; negative regulation of ATPase activity; regulation of heart contraction; muscle filament sliding

Disease: Cardiomyopathy, Familial Restrictive, 3; Cardiomyopathy, Dilated, 1d; Cardiomyopathy, Familial Hypertrophic, 2

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