Anti -Orexin 2 Receptor (Orexin Receptor 2, Orexin Receptor-2, OX2R, CD200 Cell Surface Glycoprotein Receptor, CD200 Receptor 1, CD200R1, CD200R, Cell Surface Glycoprotein CD200 Receptor 1, Cell Surface Glycoprotein OX2 Receptor 1, CRTR2, Hypocretin 2 Receptor

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 6; NC_000006.11 (55039071..55147538). Location: 6p12

Monoclonal

IgG1

OX108

Mouse

Recognizes human CD200R.

Purified
Purified

Supplied as a liquid in PBS, 0.09% sodium azide, 1% BSA. Labeled with FITC.

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light.

Small volumes of anti-HCRTR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

In humans CD200R is expressed primarily by peripheral blood monocytes and neutrophils but also by other leukocytes including T-lymphocytes and mast cells (1). Studies suggest that CD200-CD200R interaction may be involved in the control of myeloid cellular function.

Antibodies; Abs to Receptors

Flow Cytometry (FC/FACS)

Suitable for use in Flow Cytometry.
Dilution: Flow Cytometry: 10ul labels of a neat working dilution to 10e6 cells in 100ul.

50,694 Da[Similar Products]

hypocretin (orexin) receptor 2

orexin receptor type 2; ox2-R; ox-2-R; orexin type-2 receptor; hypocretin receptor type 2

Orexin receptor type 2

Ox-2-R; Ox2-R; Ox2R??[Similar Products]

OX2R_HUMAN

The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]

HCRTR2: Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6p12

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: neuropeptide receptor activity; orexin receptor activity; peptide hormone binding; peptide binding

Biological Process: synaptic transmission; neuropeptide signaling pathway; circadian sleep/wake cycle process; feeding behavior; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); cellular response to hormone stimulus; regulation of circadian sleep/wake cycle, sleep

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