Goat Anti-Orexin Receptor 2 Antibody; HCRTR2; hypocretin (orexin) receptor 2; OX2R; hypocretin receptor type 2; orexin receptor type 2; ox-2-R; ox2-R; HCRTR2 antibody; hypocretin (orexin) receptor 2 antibody; OX2R antibody; hypocretin receptor type 2 antibody; orexin receptor type 2 antibody; ox-2-R antibody; ox2-R antibody; Orexin Receptor 2; Orexin Receptor 2 (aa405-419)

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Goat

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul (lot specific)

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Manufactured in an ISO 9001:2008 Certified Laboratory.

Small volumes of anti-HCRTR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Peptide ELISA (EIA), Western Blot (WB)

Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 50kDa band observed in Mouse fetal Brain lysates (calculated MW of 52.5kDa according to Mouse NP_945200.1). Recommended concentration: 0.5-2ug/ml.

(0.5ug/ml) staining of Mouse fetal Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

50,694 Da

hypocretin receptor 2

orexin receptor type 2

Orexin receptor type 2

Ox-2-R; Ox2-R; Ox2R??[Similar Products]

OX2R_HUMAN

The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]

HCRTR2: Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p12

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: neuropeptide receptor activity; orexin receptor activity; peptide binding; peptide hormone binding

Biological Process: cellular response to hormone stimulus; circadian sleep/wake cycle process; feeding behavior; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); neuropeptide signaling pathway; regulation of circadian sleep/wake cycle, sleep; synaptic transmission

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