Product Name
NLRP12, cDNA Clone
Full Product Name
NLRP12 cDNA Clone
Product Gene Name
NLRP12 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgctacgaa ccgcaggcag ggacggcctc tgtcgcctgt ccacctactt ggaagaactc gaggctgtgg aactgaagaa gttcaagtta tacctgggga ccgcgacaga gctgggagaa ggcaagatcc cctggggaag catggagaag gccggtcccc tggaaatggc ccagctgctc atcacccact tcgggccaga ggaggcctgg aggttggctc tcagcacctt tgagcggata aacaggaagg acctgtggga gagaggacag agagaggacc tggtgaggga taccccacct ggtggcccgt cctcacttgg gaaccagtca acatgccttc tggaagtctc tcttgtcact ccaagaaaag atccccagga aacctacagg gactatgtcc gcaggaaatt ccggctcatg gaagaccgca atgcgcgcct aggggaatgt gtcaacctca gccaccggta cacccggctc ctgctggtga aggagcactc aaaccccatg caggtccagc agcagcttct ggacacaggc cggggacacg cgaggaccgt gggacaccag gctagcccca tcaagataga gaccctcttt gagccagacg aggagcgccc cgagccaccg cgcaccgtgg tcatgcaagg cgcggcaggg ataggcaagt ccatgctggc acacaaggtg atgctggact gggcggacgg gaagctcttc caaggcagat ttgattatct cttctacatc aactgcaggg agatgaacca gagtgccacg gaatgcagca tgcaagacct catcttcagc tgctggcctg agcccagcgc gcctctccag gagctcatcc gagttcccga gcgcctcctt ttcatcatcg acggcttcga tgagctcaag ccttctttcc acgatcctca gggaccctgg tgcctctgct gggaggagaa acggcccacg gagctgcttc ttaacagctt aattcggaag aagctgctcc ctgagctatc tttgctcatc accacacggc ccacggcttt ggagaagctc caccgtctgc tggagcaccc caggcatgtg gagatcctgg gcttctctga ggcagaaagg aaggaatact tctacaagta tttccacaat gcagagcagg cgggccaagt cttcaattac gtgagggaca acgagcctct cttcaccatg tgcttcgtcc ccctggtgtg ctgggtggtg tgtacctgcc tccagcagca gctggagggt ggggggctgt tgagacagac gtccaggacc accactgcag tgtacatgct ctacctgctg agtctgatgc aacccaagcc gggggccccg cgcctccagc ccccacccaa ccagagaggg ttgtgctcct tggcggcaga tgggctctgg aatcagaaaa tcctatttga ggagcaggac ctccggaagc acggcctaga cggggaagac gtctctgcct tcctcaacat gaacatcttc cagaaggaca tcaactgtga gaggtactac agcttcatcc acttgagttt ccaggaattc tttgcagcta tgtactatat cctggacgag ggggagggcg gggcaggccc agaccaggac gtgaccaggc tgttgaccga gtacgcgttt tctgaaagga gcttcctggc actcaccagc cgcttcctgt ttggactcct gaacgaggag accaggagcc acctggagaa gagtctctgc tggaaggtct cgccgcacat caagatggac ctgttgcagt ggatccaaag caaagctcag agcgacggct ccaccctgca gcagggctcc ttggagttct tcagctgctt gtacgagatc caggaggagg agtttatcca gcaggccctg agccacttcc aggtgatcgt ggtcagcaac attgcctcca agatggagca catggtctcc tcgttctgtc tgaagcgctg caggagcgcc caggtgctgc acttgtatgg cgccacctac agcgcggacg gggaagaccg cgcgaggtgc tccgcaggag cgcacacgct gttggtgcag ctaccagaga ggaccgttct gctggacgcc tacagtgaac atctggcagc ggccctgtgc accaatccaa acctgataga gctgtctctg taccgaaatg ccctgggcag ccggggggtg aagctgctct gtcaaggact cagacacccc aactgcaaac ttcagaacct gaggctgaag aggtgccgca tctccagctc agcctgcgag gacctctctg cagctctcat agccaataag aatttgacaa ggatggatct cagtggcaac ggcgttggat tcccaggcat gatgctgctt tgcgagggcc tgcggcatcc ccagtgcagg ctgcagatga ttcagttgag gaagtgtcag ctggagtccg gggcttgtca ggagatggct tctgtgctcg gcaccaaccc acatctggtt gagttggacc tgacaggaaa tgcactggag gatttgggcc tgaggttact atgccaggga ctgaggcacc cagtctgcag actacggact ttgtggctga agatctgccg cctcactgct gctgcctgtg acgagctggc ctcaactctc agtgtgaacc agagcctgag agagctggac ctgagcctga atgagctggg ggacctcggg gtgctgctgc tgtgtgaggg cctcaggcat cccacgtgca agctccagac cctgcggttg ggcatctgcc ggctgggctc tgccgcctgt gagggtcttt ctgtggtgct ccaggccaac cacaacctcc gggagctgga cttgagtttc aacgacctgg gagactgggg cctgtggttg ctggctgagg ggctgcaaca tcccgcctgc agactccaga aactgtggct ggatagctgt ggcctcacag ccaaggcttg tgagaatctt tacttcaccc tggggatcaa ccagaccttg accgaccttt acctgaccaa caacgcccta ggggacacag gtgtccgact gctttgcaag cggctgagcc atcctggctg caaactccga gtcctctggt tatttgggat ggacctgaat aaaatgaccc acagtaggtt ggcagcgctt cgagtaacaa aaccttattt ggacattggc tgctga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of NLRP12 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for NLRP12. It may not necessarily be applicable to this product.
NCBI Accession #
BC028069
[Other Products]
UniProt Secondary Accession #
Q8NEU4; Q9BY26; A8MTQ2; B3KTE7[Other Products]
UniProt Related Accession #
P59046[Other Products]
Molecular Weight
120,329 Da
NCBI Official Full Name
Homo sapiens NLR family, pyrin domain containing 12, mRNA
NCBI Official Synonym Full Names
NLR family pyrin domain containing 12
NCBI Official Symbol
NLRP12??[Similar Products]
NCBI Official Synonym Symbols
RNO; PAN6; RNO2; FCAS2; NALP12; PYPAF7; CLR19.3
??[Similar Products]
NCBI Protein Information
NACHT, LRR and PYD domains-containing protein 12
UniProt Protein Name
NACHT, LRR and PYD domains-containing protein 12
UniProt Synonym Protein Names
Monarch-1; PYRIN-containing APAF1-like protein 7; Regulated by nitric oxide
Protein Family
NACHT, LRR and PYD domains-containing protein
UniProt Gene Name
NLRP12??[Similar Products]
UniProt Synonym Gene Names
NALP12; PYPAF7; RNO??[Similar Products]
UniProt Entry Name
NAL12_HUMAN
NCBI Summary for NLRP12
This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
UniProt Comments for NLRP12
NLRP12: May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK. Defects in NLRP12 are the cause of familial cold autoinflammatory syndrome type 2 (FCAS2). FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold. Belongs to the NLRP family. 5 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 19q13.42
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding
Biological Process: inhibition of NF-kappaB transcription factor; negative regulation of cytokine secretion; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of inflammatory response; negative regulation of interleukin-1 secretion; negative regulation of interleukin-6 biosynthetic process; negative regulation of protein amino acid autophosphorylation; negative regulation of signal transduction; negative regulation of Toll signaling pathway; positive regulation of MHC class I biosynthetic process; regulation of caspase activity; regulation of I-kappaB kinase/NF-kappaB cascade; release of cytoplasmic sequestered NF-kappaB
Disease: Familial Cold Autoinflammatory Syndrome 2
Research Articles on NLRP12
1. NLRX1, NLRP12 and NLRC3 negatively modulate the host immune response following virus exposure. (Review)
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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