A disintegrin and metalloproteinase with thrombospondin motifs 2; ADAM-TS 2; ADAM-TS2; ADAMTS-2; Procollagen I N-proteinase; PC I-NP; Procollagen I/II amino propeptide-processing

For Research Use Only. Not for use in diagnostic procedures.

Recombinant and natural Human ADAM-TS 2

For long term storage, please store the entire kit at -20 degree C.

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Small volumes of ADAMTS2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS2881649 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAMTS2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ADAMTS2. The ELISA analytical biochemical technique of the MBS2881649 kit is based on ADAMTS2 antibody-ADAMTS2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ADAMTS2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ADAMTS2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Intended Uses: This immunoassay kit allows for the in vitro quantitative determination of target antigen concentrations in serum, plasma, tissue homogenates?cell culture supernates or other biological fluids.

61,756 Da

ADAM metallopeptidase with thrombospondin type 1 motif 2

A disintegrin and metalloproteinase with thrombospondin motifs 2

A disintegrin and metalloproteinase with thrombospondin motifs 2

PCINP; PCPNI; ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP; pNPI??[Similar Products]

ATS2_HUMAN

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature procollagen N-proteinase. This proteinase excises the N-propeptide of the fibrillar procollagens types I-III and type V. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

ADAMTS2: Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis. Defects in ADAMTS2 are the cause of Ehlers-Danlos syndrome type 7C (EDS7C). EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS7C is marked by extremely fragile tissues, hyperextensible skin and easy bruising. Facial skin contains numerous folds, as in the cutis laxa syndrome. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Protease; Extracellular matrix; Motility/polarity/chemotaxis; Secreted, signal peptide; EC 3.4.24.14

Chromosomal Location of Human Ortholog: 5qter

Cellular Component: extracellular region; proteinaceous extracellular matrix

Molecular Function: metalloendopeptidase activity; metallopeptidase activity; zinc ion binding

Biological Process: collagen catabolic process; collagen fibril organization; extracellular matrix organization and biogenesis; lung development; protein processing; skin development; spermatogenesis

Disease: Ehlers-danlos Syndrome, Type Vii, Autosomal Recessive

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