Product Name
4-1BBR, Polyclonal Antibody
Full Product Name
4-1BBR Antibody
Product Synonym Names
4-1BB Receptor
Product Gene Name
anti-4-1BBR antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
Affinity purified
Form/Format
100 ug (0.5 mg/ml) affinity purified rabbit anti-human 4-1BBR polyclonal antibody in PBS (pH 7.2) containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Appearance: Colorless liquid
Concentration
0.5 mg/ml (lot specific)
Immunogen
Recombinant human 4-1BBR
Handling
The antibody solution should be gently mixed before use.
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Other Notes
Small volumes of anti-4-1BBR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-4-1BBR antibody
Background: Human 4-1BB Receptor (4-1BBR) is an inhibitor of 4-1BBL and can block 4-1BBL bioactivity. Human 4-1BBR is a 17.7 kDa protein containing 167 amino acid residues.
Applications Tested/Suitable for anti-4-1BBR antibody
Western Blot (WB)
Application Notes for anti-4-1BBR antibody
Western Blot analysis (0.5-2.0 ug/ml). Per researcher's feedback, it can also be used in Neutralization (2-4 ug/ml). However, the optimal conditions should be determined individually.
Testing Data of anti-4-1BBR antibody
NCBI/Uniprot data below describe general gene information for 4-1BBR. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001552
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NCBI GenBank Nucleotide #
NM_001561.5
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UniProt Related Accession #
Q07011; AAB34924[Other Products]
Molecular Weight
27,899 Da
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 9
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 9
NCBI Official Symbol
TNFRSF9??[Similar Products]
NCBI Official Synonym Symbols
ILA; 4-1BB; CD137; CDw137
??[Similar Products]
NCBI Protein Information
tumor necrosis factor receptor superfamily member 9
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 9
UniProt Synonym Protein Names
4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA; CD_antigen: CD137
UniProt Gene Name
TNFRSF9??[Similar Products]
UniProt Synonym Gene Names
CD137; ILA??[Similar Products]
UniProt Entry Name
TNR9_HUMAN
NCBI Summary for 4-1BBR
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]
UniProt Comments for 4-1BBR
TNFRSF9: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 1p36
Cellular Component: extracellular space; integral to plasma membrane; external side of plasma membrane
Molecular Function: cytokine binding; receptor activity
Biological Process: negative regulation of cell proliferation; apoptosis
Research Articles on 4-1BBR
1. upregulation of CD137 expression through LMP1 by EBV promotes cell survival in T or NK cells
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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