Product Name
cTnT, Clone 3B10 (TNNT2), Monoclonal Antibody
Full Product Name
Anti Human cTnT, Clone 3B10
Product Gene Name
anti-TNNT2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_000001.10 (201328142..201346805, complement). Location: 1q32
3D Structure
ModBase 3D Structure for P45379
Host
Host: Mouse; Source: Hybridoma cell culture
Purity/Purification
IgG fraction
Form/Format
Frozen liquid
Concentration
1.0 mg/ml (lot specific)
Immunogen
Full length native protein (purified) (Human).
Target Information
Recognises cTnT
Target Molecular Weight
36000
Buffer
0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6
Extinction Coefficient
1.36
Preparation and Storage
Store at -70 degree C. Shelf Life: 5 years from delivery
Other Notes
Small volumes of anti-TNNT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TNNT2 antibody
Mouse monoclonal antibody to human Cardiac Troponin T (cTnT). IgG fraction purified by immobilized Protein G. Detects cTnT in western blot under non-reducing and reducing conditions. Cross reacts with human Skeletal Troponin T (sTNT, TNNT1). Clone 3B10-G1
Product Categories/Family for anti-TNNT2 antibody
Cardiac Troponin T (cTnT); Monoclonal Antibodies to Human Cardiac Troponin T
Applications Tested/Suitable for anti-TNNT2 antibody
ELISA (EIA), Western Blot (WB)
Testing Data of anti-TNNT2 antibody
NCBI/Uniprot data below describe general gene information for TNNT2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000355.2
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NCBI GenBank Nucleotide #
NM_000364.3
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UniProt Primary Accession #
P45379
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UniProt Secondary Accession #
O60214; Q99596; Q99597; Q9BUF6; Q9UM96; A2TDB9; A8K3K6[Other Products]
UniProt Related Accession #
P45379[Other Products]
NCBI Official Full Name
troponin T, cardiac muscle isoform 1
NCBI Official Synonym Full Names
troponin T type 2 (cardiac)
NCBI Official Symbol
TNNT2??[Similar Products]
NCBI Official Synonym Symbols
CMH2; RCM3; TnTC; cTnT; CMPD2; LVNC6
??[Similar Products]
NCBI Protein Information
troponin T, cardiac muscle; troponin T2, cardiac; cardiomyopathy, hypertrophic 2; cardiomyopathy, dilated 1D (autosomal dominant)
UniProt Protein Name
Troponin T, cardiac muscle
UniProt Synonym Protein Names
Cardiac muscle troponin T
UniProt Gene Name
TNNT2??[Similar Products]
UniProt Synonym Gene Names
TnTc; cTnT??[Similar Products]
UniProt Entry Name
TNNT2_HUMAN
NCBI Summary for TNNT2
The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for TNNT2
TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the ***** heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal ***** heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing ***** heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 1q32
Cellular Component: sarcomere; troponin complex; cytosol; striated muscle thin filament
Molecular Function: troponin C binding; structural constituent of cytoskeleton; troponin I binding; ATPase activity; tropomyosin binding; actin binding
Biological Process: positive regulation of ATPase activity; atrial cardiac muscle morphogenesis; regulation of muscle contraction; metabolic process; ventricular cardiac muscle morphogenesis; sarcomere organization; response to calcium ion; negative regulation of ATPase activity; regulation of heart contraction; muscle filament sliding
Disease: Cardiomyopathy, Familial Restrictive, 3; Cardiomyopathy, Dilated, 1d; Cardiomyopathy, Familial Hypertrophic, 2
Research Articles on TNNT2
1. For brain surgery cTnT was undetectable both before and after surgery.
Precautions
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Disclaimer
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