Product Gene Name
anti-SMG-1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P45379
Purity/Purification
Protein A purified
Immunogen
SMG1 / ATX antibody was raised against sMG1 (-, 2922 a.a. ~ 3032 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Other Notes
Small volumes of anti-SMG-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SMG-1 antibody
SMG1 encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. This protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein.
The absence of a protein called SMG1 could be a contributing factor in the development of Parkinson's disease and other related neurological disorders, according to a study led by the Translational Genomics Research Institute (TGen).
Applications Tested/Suitable for anti-SMG-1 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-SMG-1 antibody
ICC: 1:500 -1:1000
IHC: 1:500 -1:1000
WB: 1:5,000 - 1:10,000
Testing Data of anti-SMG-1 antibody
Immunoperoxidase of monoclonal antibody to SMG1 on formalin-fixed paraffin-embedded human adrenal gland. [antibody concentration 1.5 ug/ml inset: : Western blot of SMG1 expression in HeLa NE.
Immunohistochemistry (IHC) of anti-SMG-1 antibody
Detection limit for recombinant GST tagged SMG1 is approximately 0.1 ng/ml as a capture antibody.
NCBI/Uniprot data below describe general gene information for SMG-1. It may not necessarily be applicable to this product.
NCBI Accession #
AAK92231.1
[Other Products]
UniProt Primary Accession #
P45379
[Other Products]
UniProt Related Accession #
P45379[Other Products]
NCBI Official Full Name
cardiac troponin T
NCBI Official Synonym Full Names
troponin T2, cardiac type
NCBI Official Symbol
TNNT2??[Similar Products]
NCBI Official Synonym Symbols
CMH2; RCM3; TnTC; cTnT; CMD1D; CMPD2; LVNC6
??[Similar Products]
NCBI Protein Information
troponin T, cardiac muscle
UniProt Protein Name
Troponin T, cardiac muscle
UniProt Synonym Protein Names
Cardiac muscle troponin T
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
TNNT2??[Similar Products]
UniProt Synonym Gene Names
TnTc; cTnT??[Similar Products]
UniProt Entry Name
TNNT2_HUMAN
NCBI Summary for SMG-1
The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for SMG-1
TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the ***** heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal ***** heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing ***** heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing.
Protein type: Motor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1q32
Cellular Component: sarcomere; troponin complex; cytosol; striated muscle thin filament
Molecular Function: troponin C binding; structural constituent of cytoskeleton; troponin I binding; ATPase activity; tropomyosin binding; actin binding
Biological Process: positive regulation of ATPase activity; regulation of muscle contraction; atrial cardiac muscle morphogenesis; metabolic process; ventricular cardiac muscle morphogenesis; sarcomere organization; response to calcium ion; negative regulation of ATPase activity; regulation of heart contraction; muscle filament sliding
Disease: Cardiomyopathy, Familial Restrictive, 3; Cardiomyopathy, Dilated, 1d; Cardiomyopathy, Familial Hypertrophic, 2
Research Articles on SMG-1
1. NT-proBNP and hs-cTnT are useful biomarkers in assessment of hypertrophy and fibrosis in hypertrophic cardiomyopathy.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
