Product Name
Filamin (FLNB), Monoclonal Antibody
Popular Item
Full Product Name
Filamin antibody
Product Synonym Names
Monoclonal Filamin; Anti-Filamin
Product Gene Name
anti-FLNB antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O75369
Species Reactivity
Chicken, Guinea Pig, Human, Rabbit, Rat
Purity/Purification
Filamin antibody was purified by affniity chromatography.
Form/Format
Protein A purified and supplied in PBS with 1 mg/ml BSA, and 10mM NaN3.
Concentration
0.1 mg/ml (lot specific)
Biological Significance
Filamin is a structural protein that forms flexible cross-links between two actin filaments. Filamin is a homodimer of polypeptide chains each joined to the other at one end with an actin ath the other. It is present in smooth muscle, fibroblasts, platelets and lymphocytes.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.
Immunogen
Filamin antibody was raised in mouse using platelet filamin as the immunogen.
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-FLNB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FLNB antibody
Mouse monoclonal Filamin antibody
Product Categories/Family for anti-FLNB antibody
Cancer
Applications Tested/Suitable for anti-FLNB antibody
Immunohistochemistry (IHC), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-FLNB antibody
WB: 1:1,000-1:4,000
NCBI/Uniprot data below describe general gene information for FLNB. It may not necessarily be applicable to this product.
NCBI Accession #
AAF72339.1
[Other Products]
UniProt Primary Accession #
O75369
[Other Products]
UniProt Secondary Accession #
Q13706; Q59EC2; Q60FE7; Q6MZJ1; Q8WXS9; Q8WXT0; B2ZZ83; B2ZZ84; B2ZZ85; C9JKE6; C9JMC4[Other Products]
UniProt Related Accession #
O75369[Other Products]
Molecular Weight
276,939 Da[Similar Products]
NCBI Official Full Name
filamin
NCBI Official Synonym Full Names
filamin B, beta
NCBI Official Symbol
FLNB??[Similar Products]
NCBI Official Synonym Symbols
AOI; FH1; SCT; TAP; LRS1; TABP; FLN-B; FLN1L; ABP-278; ABP-280
??[Similar Products]
NCBI Protein Information
filamin-B
UniProt Protein Name
Filamin-B
UniProt Synonym Protein Names
ABP-278; ABP-280 homolog; Actin-binding-like protein; Beta-filamin; Filamin homolog 1; Fh1; Filamin-3; Thyroid autoantigen; Truncated actin-binding protein; Truncated ABP
UniProt Gene Name
FLNB??[Similar Products]
UniProt Synonym Gene Names
FLN1L; FLN3; TABP; TAP; FLN-B; Fh1; Truncated ABP??[Similar Products]
UniProt Entry Name
FLNB_HUMAN
NCBI Summary for FLNB
This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
UniProt Comments for FLNB
FLNB: a ubiquitous cytoskeletal protein that links actin filaments to membrane glycoproteins. Six alternatively spliced isoforms have been described. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoforms 1 and 2 are expressed in placenta, bone marrow, brain, umbilical vein endothelial cells, retina and skeletal muscle. Isoform 1 is predominantly expressed in prostate, uterus, liver, thyroid, stomach, lymph node, small intestine, spleen, skeletal muscle, kidney, placenta, pancreas, heart, lung, platelets, endothelial cells, megakaryocytic and erythroleukemic cell lines. Isoform 2 is predominantly expressed in spinal cord and platelets. Also expressed in thyroid adenoma, neurofibrillary tangles (NFT), senile plaques in the hippocampus and cerebral cortex in Alzheimer's disease. Isoform 3 and isoform 6 are expressed predominantly in lung, heart, skeletal muscle, testis, spleen, thymus and leukocytes. Isoform 4 and isoform 5 are expressed in heart.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3p14.3
Cellular Component: focal adhesion; cytoplasm; integral to membrane; stress fiber; plasma membrane; cell cortex; cytosol; Z disc; actin cytoskeleton
Molecular Function: identical protein binding; protein binding; actin binding
Biological Process: skeletal muscle development; cytoskeletal anchoring; cytokine and chemokine mediated signaling pathway; actin cytoskeleton organization and biogenesis; cell differentiation; signal transduction
Disease: Larsen Syndrome; Boomerang Dysplasia; Atelosteogenesis, Type I; Spondylocarpotarsal Synostosis Syndrome; Atelosteogenesis, Type Iii
Research Articles on FLNB
1. Polymorphism at rs11720285, rs11130605 and rs9809315, all of which are located either 5' of the transcription start site or in intron 1 of the FLNB gene has been identified as significantly associated with BMD in Caucasian women.
Precautions
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Disclaimer
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