Product Name
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr), Recombinant Protein
Full Product Name
Recombinant Drosophila melanogaster 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr), partial
Product Gene Name
Hmgcr recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MIGRLFRAHG EFCASHPWEV IVALLTITAC MLTVDKNNTL DASSGLGTAT ASAAAAGGSG SGAGSGASGT IPPSSMGGSA TSSRHRPCHG WSQSCDGLEA EYNAADVILM TIVRCTAVLY CYYQFCSLHR LGSKYVLGIA GLFTVFSSFI FTTAIIKFLG SDISELKDAL FFLLLVIDLS NSGRLAQLAL SGSNQAEVTQ NIARGLELLG PAISLDTIVE VLLVGVGTLS GVQRLEVLCM FAVLSVLVNY VVFMTFYPAC LSLIFDLSRS GVDMSVVREK AKGSLLLKSL TEEEQKANPV LQRVKLIMTT GLMAVHIYSR VAFSGSDYDA VDKTLTPTLS LNVSNNRTES GEIADIIIKW LTMSADHIVI SIVLIALVVK FICFDNRDPL PDQLRQSGPV AIAAKASQTT PIDEEHVEQE KDTENSAAVR TLLFTIEDQS SANASTQTDL LPLRHRLVGP IKPPRPVQEC LDILNSTEEG SGPAALSDEE IVSIVHAGGT HCPLHKIESV LDDPERGVRI RRQIIGSRAK MPVGRLDVLP YEHFDYRKVL NACCENVLGY VPIPVGYAGP LLLDGETYYV PMATTEGALV ASTNRGCKAL SVRGVRSVVE DVGMTRAPCV RFPSVARAAE AKSWIENDEN YRVVKTEFDS TSRFGRLKDC HIAMDGPQLY IRFVAITGDA MGMNMVSKGA EMALRRIQLQ FPDMQIISLS GNFCCDKKPA AINWIKGRGK RVVTECTISA ATLRSVLKTD AKTLVECNKL KNMGGSAMAG SIGGNNAHAA NMVTAVFLAT GQDPAQNVTS SNCSTAMECW AENSEDLYMT CTMPSLEVGT VGGGTGLPGQ SACLEMLGVR GAHATRPGDN AKKLAQIVCA TVMAGELSLM AALVNSDLVK SHMRHNRSSI AVNSANNPLN VTVSSCSTIS
3D Structure
ModBase 3D Structure for P14773
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Drosophila melanogaster (Fruit fly)
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Hmgcr recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Hmgcr. It may not necessarily be applicable to this product.
NCBI Accession #
NP_732900.1
[Other Products]
NCBI GenBank Nucleotide #
NM_170089.2
[Other Products]
UniProt Primary Accession #
P14773
[Other Products]
UniProt Secondary Accession #
Q9VCI8; A4V3A8[Other Products]
UniProt Related Accession #
P14773[Other Products]
Molecular Weight
98,317 Da
NCBI Official Full Name
HMG coenzyme A reductase
NCBI Official Synonym Full Names
HMG Coenzyme A reductase
NCBI Official Symbol
Hmgcr??[Similar Products]
NCBI Official Synonym Symbols
BcDNA:LD15354; bro1; bs32f05.y1; CG10367; clb; Clb; DmelCG10367; DmHMG-CoAr; Hmg; HmG-CoAR; hmgc; HMGCoAr; HMGCoAR; HMGCoARr; hmgcr; HMGCR; HMGCR_Dm; HMGR; hmgrc; l(3)01152; l(3)04684
??[Similar Products]
NCBI Protein Information
CG10367 gene product from transcript CG10367-RA
UniProt Protein Name
3-hydroxy-3-methylglutaryl-coenzyme A reductase
UniProt Gene Name
Hmgcr??[Similar Products]
UniProt Synonym Gene Names
HmG-CoAR; HMG-CoA reductase??[Similar Products]
UniProt Comments for Hmgcr
Synthesis of mevalonate for the production of non-sterol isoprenoids, which are essential for growth differentiation. Provides spatial information during embryogenesis to guide migrating primordial germ cells (the pole cells) from the ectoderm to the mesoderm. Also required for association of the pole cells with the gonadal mesoderm.
Research Articles on Hmgcr
1. The specificity and evolutionary conservation of the HMGCoAr pathway for germ cells suggest that an attractant common to invertebrates and vertebrates guides germ cells in early embryos.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
