Recombinant B1 bradykinin receptor (BDKRB1); B1 bradykinin receptor; B1R; BK-1 receptor

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 14; NC_000014.8 (96722547..96731100). Location: 14q32.1-q32.2

E Coli or Yeast or Baculovirus or Mammalian Cell

>=90% (lot specific)

Liquid containing glycerol

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterile filter available upon request.

Low endotoxin available upon request.

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of BDKRB1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

40,495 Da[Similar Products]

bradykinin receptor B1

B1 bradykinin receptor; BK-1 receptor; bradykinin receptor 1; bradykinin B1 receptor

B1 bradykinin receptor

BRADYB1; B1R??[Similar Products]

BKRB1_HUMAN

Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

BKR1: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation. Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.

Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 14q32.1-q32.2

Cellular Component: neuron projection; integral to plasma membrane; endoplasmic reticulum; plasma membrane

Molecular Function: bradykinin receptor activity; protein binding; peptide binding

Biological Process: elevation of cytosolic calcium ion concentration; cell migration; negative regulation of protein amino acid phosphorylation; response to mechanical stimulus; positive regulation of leukocyte migration; protein kinase C activation; response to lipopolysaccharide; negative regulation of blood pressure; negative regulation of cell growth; positive regulation of release of sequestered calcium ion into cytosol; inflammatory response; sensory perception of pain

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