Product Name
Nuclear receptor subfamily 0 group B member 1 (Nr0b1), Recombinant Protein
Full Product Name
Recombinant Rat Nuclear receptor subfamily 0 group B member 1 (Nr0b1)
Product Gene Name
Nr0b1 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-472aa, Full length protein
Sequence
MAGEDHPWHG SILYNLLMSA KQKHGSREER EVRLGAQCWG CACGTQPVLG GEGLPGGQAL SLLYRCCFCG ENHPRQGGIL YSMLTNARQP SGATEAPRAR FRTPCWGCAC SNAKPLVGRX GLPAGQVPSL LYRCCFCGKK HPRQGSILYS LLTNAQQTHV SREVPEAHRG GEWWQLSYCT HNVGGPEGLQ STQAMAFLYR SYVCCEEQPQ QSSVASDTPV RADQTPAAPQ EQPRAPWWDT SSGVQRPIAL KDPQVVCEAA SAGLLKTLRF VKYLPCFQIL PLDQQLVLVR SCWAPLLMLE LAQDHLHFEM MEISEPNLMH EMLTTRRQET EGPEPADPQA TEQPQTVSAE AGHVLSVAAV QAIKSFFFKC WSLNIDTKEY AYLKGTVLFN PDLPGLQCVK YIESLQWRTQ QILTEHIRLM QREYQIRSAE LNSALFLLRF INTDVVTELF FRPIIGAVSM DDMMLEMLCA KL
3D Structure
ModBase 3D Structure for P70503
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Nr0b1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Nr0b1 recombinant protein
This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
NCBI/Uniprot data below describe general gene information for Nr0b1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_445769.1
[Other Products]
NCBI GenBank Nucleotide #
NM_053317.1
[Other Products]
UniProt Primary Accession #
P70503
[Other Products]
UniProt Secondary Accession #
Q63152[Other Products]
UniProt Related Accession #
P70503[Other Products]
Molecular Weight
52,756 Da
NCBI Official Full Name
nuclear receptor subfamily 0 group B member 1
NCBI Official Synonym Full Names
nuclear receptor subfamily 0, group B, member 1
NCBI Official Symbol
Nr0b1??[Similar Products]
NCBI Official Synonym Symbols
Ahch; DAX-1
??[Similar Products]
NCBI Protein Information
nuclear receptor subfamily 0 group B member 1
UniProt Protein Name
Nuclear receptor subfamily 0 group B member 1
UniProt Synonym Protein Names
Nuclear receptor DAX-1
Protein Family
Nuclear receptor subfamily
UniProt Gene Name
Nr0b1??[Similar Products]
UniProt Synonym Gene Names
Ahch; Dax1??[Similar Products]
NCBI Summary for Nr0b1
human homolog is an orphan nuclear hormone receptor [RGD, Feb 2006]
UniProt Comments for Nr0b1
Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency ().
Research Articles on Nr0b1
1. High fat diet aggravates BDE47-inhibited testosterone production through hyperinsulinemia, and the accumulation of testicular BDE47 that induces the up-regulation of DAX-1 and the subsequent down-regulation of steroidogenic proteins.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
