ADAM-TS 17; ADAM-TS17; ADAMTS-17; ADAMTS17; ATS17; FLJ16363; FLJ32769

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

The antibody detects endogenous levels of total ADAMTS17 protein.

Antigen affinity purification.

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

2.6 mg/ml (lot specific)

Store at -20 degree C

Small volumes of anti-ADAMTS17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by ADAMTS19, another family member. The function of this protein has not been determined.

Total protein Ab

Western Blot (WB), Immunohistochemistry (IHC)

Western blotting: 1:500-1:2000
Immunohistochemistry: 1:50-1:200

Gel: 8%SDS-PAGE Lysate: 40ug NIH/3T3 cell Primary antibody: 1/1300 dilution Secondary antibody dilution: 1/8000 Exposure time: 1 hour

Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/60.

54,757 Da

ADAM metallopeptidase with thrombospondin type 1 motif, 17

A disintegrin and metalloproteinase with thrombospondin motifs 17

A disintegrin and metalloproteinase with thrombospondin motifs 17

ADAM-TS 17; ADAM-TS17; ADAMTS-17??[Similar Products]

ATS17_HUMAN

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by ADAMTS19, another family member. The function of this protein has not been determined. [provided by RefSeq, Jul 2008]

ADAMTS17: Defects in ADAMTS17 are the cause of Weill-Marchesani- like syndrome (WMLS). It is a disorder characterized by many of the key features of Weill-Marchesani syndrome, including lenticular myopia, ectopia lentis, glaucoma, spherophakia and short stature. However, the characteristic brachydactyly or decreased joint flexibility of Weill-Marchesani syndrome are absent. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; Secreted; Motility/polarity/chemotaxis; EC 3.4.24.-; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 15q24

Cellular Component: proteinaceous extracellular matrix

Molecular Function: zinc ion binding; metalloendopeptidase activity

Biological Process: proteolysis

Disease: Weill-marchesani-like Syndrome

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