Transforming Growth Factor beta Receptor Type 1 (TGFBR1); ALK5

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

This antibody recognizes TGFbetaR1protein. This antibody reacts with human, rat and mouse. The other species are not tested.

The Rabbit IgG is purified by Epitope Affinity Purification.

This affinity purified antibody is supplied in sterile Phosphate-buffered saline (pH7.2) containing antibody stabilizer

The antibodies are stable for 12 months from date of receipt when stored at ?20 degree C to ?70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.

Small volumes of anti-TGF beta R1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Transforming growth factor ? isoforms (TGF-?1, 2, 3) play vital roles in regulating cellular growth and differentiation, and they signal through a highly restricted subset of receptors known as TGF-? type I receptor (T?R-I) and TGF-? type II receptor (T?R-II). TGF-?'s specificity for T?R-I has been proposed to arise from its pre-helix extension, a five-residue loop that binds in the cleft between TGF-? and T?R-II. TGF-? binds with high affinity to the type II receptor, a transmembrane protein with a cytoplasmic serine/threonine kinase domain, which requires both its kinase activity and association with another TGF beta-binding protein, the type I receptor, to signal growth inhibition and early gene responses. Receptors I and II associate as interdependent components of a heteromeric complex: receptor I requires receptor II to bind TGF beta, and receptor II requires receptor I to signal. Mutations in T?R-I and T?R-II gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).

ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)

Western Blot: 0.1-1 ug/ml
ELISA: 0.01-0.1 ug/ml
Immunoprecipitation: 2-5 ug/ml
IHC: Not tested
Flow cytometry: Not tested
Optimal dilutions should be determined by researchers for the specific applications.

The cell lysate derived from HEK293 transfected with full length of TGFbetaR1 was immunoprobed by Rabbit anti-TGFbetaR1 (Cat#MBS460088) at 1:500. An immunoreactive band is observed around ~55 kDa

~55 kDa

transforming growth factor, beta receptor 1

TGF-beta receptor type-1

TGF-beta receptor type-1

TGFR-1; SKR4; TGF-beta receptor type I; TbetaR-I??[Similar Products]

forms a heteromeric receptor complex with TGF-beta type II receptor that binds TGF-beta and mediates TGF-beta signalling [RGD, Feb 2006]

TGFBR1: a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Found in all tissues; most abundant in placenta and least abundant in brain and heart.

Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Receptor, misc.; STKR family; TKL group; Type1 subfamily

Chromosomal Location of Human Ortholog: 5q22

Cellular Component: apical plasma membrane; basolateral plasma membrane; caveola; cell; cell surface; endosome; intracellular membrane-bound organelle; lipid raft; membrane; plasma membrane; protein complex; receptor complex; tight junction

Molecular Function: ATP binding; growth factor binding; protein complex binding; protein heterodimerization activity; protein kinase activity; protein serine/threonine kinase activity; punt binding; receptor binding; receptor signaling protein activity; receptor signaling protein serine/threonine kinase activity; SMAD binding; transforming growth factor beta binding; transforming growth factor beta receptor activity; transforming growth factor beta receptor activity, type I; ubiquitin protein ligase binding

Biological Process: activation of MAPKK activity; activin receptor signaling pathway; aging; angiogenesis; anterior/posterior pattern formation; artery morphogenesis; blastocyst development; cell motility involved in cell locomotion; collagen fibril organization; embryo implantation; embryonic cranial skeleton morphogenesis; endothelial cell activation; endothelial cell migration; epithelial to mesenchymal transition; germ cell migration; gut development; heart development; in utero embryonic development; kidney development; lens development in camera-type eye; lung development; male gonad development; mesenchymal cell differentiation; negative regulation of apoptosis; negative regulation of chondrocyte differentiation; negative regulation of endothelial cell differentiation; negative regulation of endothelial cell proliferation; neuron fate commitment; organ regeneration; palate development; parathyroid gland development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; pharyngeal system development; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell motility; positive regulation of cell proliferation; positive regulation of endothelial cell proliferation; positive regulation of filopodium formation; positive regulation of protein kinase B signaling cascade; positive regulation of stress fiber formation; positive regulation of transcription, DNA-dependent; post-embryonic development; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cardiac muscle cell proliferation; regulation of gene expression; regulation of protein binding; regulation of protein ubiquitination; regulation of transcription, DNA-dependent; response to electrical stimulus; response to estrogen stimulus; response to hypoxia; response to organic cyclic substance; response to toxin; signal transduction; skeletal development; skeletal morphogenesis; thymus development; transforming growth factor beta receptor signaling pathway

N/A

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