For Research Use Only. Not for use in diagnostic procedures.

Supernatant - Liquid

Small volumes of anti-TGFBR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Transforming growth factor beta (TGFB) inhibits cell proliferation and stimulates cell differentiation. This is achieved through a receptor complex of types I and II TGFB receptors. The type II receptor is a transmembrane serine/threonine kinase which is able to bind TGFB and transactivate the type I receptor. TGFB receptors are found in all myometrial tissues and, in the kidney, they are found exclusively in renal tubular cells. In normal gastric mucosa, type I and II receptors are demonstrated in fundic glands, but not on surface mucous cells and in normal small bowel and colon, TGFB receptors are expressed in the epithelial cells of the upper crypts.

Antibodies; Stem Cell Research Antibodies; TGF beta RI (type1)

Immunohistochemistry (IHC)

Image: TGF Beta R (Type1) staining of paraffin embedded Human colon, ulcerative colitis. Note membrane staining of a proportion of epithelial cells and lymphocytes.

47,690 Da[Similar Products]

transforming growth factor beta receptor 1

TGF-beta receptor type-1

TGF-beta receptor type-1

ALK5; SKR4; TGFR-1; ALK-5; ALK5; SKR4; TGF-beta receptor type I; TbetaR-I??[Similar Products]

TGFR1_HUMAN

TGFBR1: a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Found in all tissues; most abundant in placenta and least abundant in brain and heart.

Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Receptor, misc.; STKR family; TKL group; Type1 subfamily

Chromosomal Location of Human Ortholog: 9q22

Cellular Component: cell surface; lipid raft; plasma membrane; receptor complex; tight junction

Molecular Function: ATP binding; growth factor binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; punt binding; receptor signaling protein activity; SMAD binding; transforming growth factor beta binding; transforming growth factor beta receptor activity; transforming growth factor beta receptor activity, type I

Biological Process: activation of MAPKK activity; activin receptor signaling pathway; anterior/posterior pattern formation; artery morphogenesis; cell cycle arrest; cell motility involved in cell locomotion; collagen fibril organization; embryonic cranial skeleton morphogenesis; endothelial cell activation; epithelial to mesenchymal transition; extracellular structure organization and biogenesis; germ cell migration; heart development; in utero embryonic development; kidney development; mesenchymal cell differentiation; negative regulation of chondrocyte differentiation; negative regulation of transforming growth factor beta receptor signaling pathway; neuron fate commitment; palate development; parathyroid gland development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; pharyngeal system development; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell motility; positive regulation of cell proliferation; positive regulation of endothelial cell proliferation; positive regulation of protein kinase B signaling cascade; positive regulation of stress fiber formation; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; regulation of cardiac muscle cell proliferation; regulation of protein ubiquitination; regulation of transcription, DNA-dependent; signal transduction; skeletal development; skeletal morphogenesis; thymus development; transforming growth factor beta receptor signaling pathway; wound healing

Disease: Multiple Self-healing Squamous Epithelioma, Susceptibility To

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.