Product Name
Absent In Melanoma 2 (AIM2), Polyclonal Antibody
Full Product Name
Biotin-Linked Polyclonal Antibody to Absent In Melanoma 2 (AIM2)
Product Synonym Names
PYHIN4; Interferon-inducible protein AIM2
Product Gene Name
anti-AIM2 antibody
[Similar Products]
Matching Pairs
Unconjugated Antibody: Absent In Melanoma 2 (MBS2026549)
Biotin Conjugated Antibody: Absent In Melanoma 2 (AIM2) (MBS2096141)
Matching Pairs
Biotin Conjugated Antibody: Absent In Melanoma 2 (AIM2) (MBS2096141)
Immunogen: Absent In Melanoma 2 (MBS2031637)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Concentration
200ug/ml (lot specific)
Immunogen
AIM2 (Met1~Thr343)
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customera??s specifications, please inquire.
Other Notes
Small volumes of anti-AIM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-AIM2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for AIM2. It may not necessarily be applicable to this product.
NCBI Accession #
EAW52795.1
[Other Products]
UniProt Secondary Accession #
Q5T3V9; Q96FG9; A8K7M7[Other Products]
UniProt Related Accession #
O14862[Other Products]
Molecular Weight
38,954 Da
NCBI Official Full Name
absent in melanoma 2
NCBI Official Synonym Full Names
absent in melanoma 2
NCBI Official Symbol
AIM2??[Similar Products]
NCBI Official Synonym Symbols
PYHIN4
??[Similar Products]
NCBI Protein Information
interferon-inducible protein AIM2
UniProt Protein Name
Interferon-inducible protein AIM2
UniProt Synonym Protein Names
Absent in melanoma 2
UniProt Gene Name
AIM2??[Similar Products]
NCBI Summary for AIM2
AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008]
UniProt Comments for AIM2
AIM2: a tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. Induced by interferon gamma. Defects in AIM2 may be a cause of microsatellite unstable colon cancers. AIM2 and various NOD-like receptors form multiprotein complexes called inflammasomes, which mediate caspase-1-dependent processing of pro-IL-1beta.
Protein type: Tumor suppressor
Chromosomal Location of Human Ortholog: 1q23.1-q23.2
Cellular Component: cytoplasm; cytosol; mitochondrion; nucleoplasm
Molecular Function: double-stranded DNA binding; identical protein binding; protein binding
Biological Process: activation of innate immune response; apoptosis; immune response; inflammatory response; innate immune response; interleukin-1 beta secretion; negative regulation of NF-kappaB transcription factor activity; positive regulation of defense response to virus by host; positive regulation of interleukin-1 beta production; positive regulation of interleukin-1 beta secretion; positive regulation of NF-kappaB transcription factor activity; positive regulation of protein oligomerization; tumor necrosis factor-mediated signaling pathway
Research Articles on AIM2
1. Overexpression of AIM2 in hepatocellular carcinoma (HCC) cells suppressed mammalian target of rapamycin (mTOR)-S6K1 pathway and further inhibited proliferation of HCC cells.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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