TGF-beta receptor type-1(TGFR-1); transforming growth factor, beta receptor 1; AAT 5 antibody; AAT5 antibody; Activin A receptor type II like kinase 53kDa antibody; Activin A receptor type II like kinase, 53kD antibody; Activin A receptor type II like protein kinase of 53kD antibody; activin A receptor type II-like kinase, 53kDa antibody; activin A receptor type II-like protein kinase of 53kD antibody; Activin receptor like kinase 5 antibody; Activin receptor-like kinase 5 antibody; ACVRLK 4 antibody; ACVRLK4 antibody; ALK 5 antibody; ALK-5 antibody; ALK5 antibody; LDS1A antibody; LDS2A antibody; MSSE antibody; Serine/threonine protein kinase receptor R4 antibody; Serine/threonine-protein kinase receptor R4 antibody; SKR 4 antibody; SKR4 antibody; TbetaR I antibody; TbetaR-I antibody; TGF beta receptor type 1 antibody; TGF beta receptor type I antibody; TGF beta type I receptor antibody; TGF-beta receptor type I antibody; TGF-beta receptor type-1 antibody; TGF-beta type I receptor antibody; TGFBR 1 antibody; TGFBR1 antibody; TGFBR1 protein antibody; TGFR 1 antibody; TGFR-1 antibody; TGFR1 antibody; TGFR1_HUMAN antibody; Transforming growth factor beta receptor 1 antibody; Transforming growth factor beta receptor I(activin A receptor type II like kinase, 53kD) antibody; Transforming growth factor beta receptor I antibody; transforming growth factor, beta receptor 1 antibody; transforming growth factor, beta receptor I(activin A receptor type II-like kinase, 53kD) antibody; Transforming growth factor-beta receptor type I antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

No cross reactivity with other proteins.

Immunogen affinity purified.

Lyophilized

At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.

Avoid repeated freezing and thawing.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-TGFBR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Background: TGFBR1, Transforming growth factor, beta receptor I is a TGF beta receptor. TGFBR1 is its human gene. The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome(LDAS). TGFB1 regulates cell cycle progression by a unique signaling mechanism that involves its binding to TGFBR2 and activation of TGFBR1. Both are transmembrane serine/threonine receptor kinases. The TGFBR1 receptor may be inactivated in many of the cases of human tumor cells refractory to TGFB-mediated cell cycle arrest. Vellucci and Reiss(1997) reported that the TGFBR1 gene is approximately 31 kb long and contains 9 exons. The organization of the segment of the gene that encodes the C-terminal portion of the serine/threonine kinase domain appears to be highly conserved among members of the gene family.

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Western Blot

Concentration: 0.1-0.5 ug/mL
Tested Species: Hu
Predicted Species: Ms Rat



Immunohistochemistry (Paraffin-embedded Section)

Concentration:0.5-1 ug/mL
Tested Species: Hu, Rat
Predicted Species: Ms
Antigen Retrieval: By Heat



Tested species : In house-tested species with positive results.

Predicted Species: Species predicted to be fit for the product based on sequence similarities,

By Heat: Boiling the paraffin sections in 10mM citrate buffer,pH 6.0, for 20 mins. is required for the staining of formalin/paraffin sections.

Other applications have not been tested.

Optimal dilutions should be determined by end users.

transforming growth factor, beta receptor 1

TGF-beta receptor type-1; tbetaR-I; TGF-beta receptor type I; TGF-beta type I receptor; activin receptor-like kinase 5; multiple self-healing squamous epithelioma; transforming growth factor beta receptor I; serine/threonine-protein kinase receptor R4; activin A receptor type II-like kinase, 53kD; activin A receptor type II-like kinase, 53kDa; transforming growth factor-beta receptor type I; activin A receptor type II-like protein kinase of 53kD; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD)

TGF-beta receptor type-1

ALK5; SKR4; TGFR-1; ALK-5; ALK5; SKR4; TGF-beta receptor type I; TbetaR-I??[Similar Products]

TGFR1_HUMAN

The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

TGFBR1: a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Found in all tissues; most abundant in placenta and least abundant in brain and heart.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Membrane protein, integral; EC 2.7.11.30; Receptor, misc.; TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 9q22

Cellular Component: tight junction; membrane; cell; plasma membrane; endosome; receptor complex

Molecular Function: metal ion binding; punt binding; protein kinase activity; transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; transforming growth factor beta binding; transforming growth factor beta receptor activity, type I; growth factor binding; receptor signaling protein activity; SMAD binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: blastocyst development; collagen fibril organization; activation of MAPKK activity; heart development; positive regulation of transcription, DNA-dependent; negative regulation of chondrocyte differentiation; activin receptor signaling pathway; cell motility involved in cell locomotion; protein amino acid phosphorylation; post-embryonic development; anterior/posterior pattern formation; extracellular structure organization and biogenesis; transforming growth factor beta receptor signaling pathway; germ cell migration; cell cycle arrest; kidney development; neuron fate commitment; embryonic cranial skeleton morphogenesis; positive regulation of cell growth; parathyroid gland development; endothelial cell activation; mesenchymal cell differentiation; regulation of gene expression; negative regulation of endothelial cell proliferation; endothelial cell migration; positive regulation of endothelial cell proliferation; lens development in camera-type eye; wound healing; regulation of protein ubiquitination; apoptosis; palate development; signal transduction; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; angiogenesis; skeletal development; positive regulation of filopodium formation; pharyngeal system development; thymus development; in utero embryonic development; male gonad development; peptidyl-threonine phosphorylation; positive regulation of cell motility; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; skeletal morphogenesis; regulation of protein binding; epithelial to mesenchymal transition; artery morphogenesis; negative regulation of transforming growth factor beta receptor signaling pathway

Disease: Multiple Self-healing Squamous Epithelioma, Susceptibility To

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