TGF-beta receptor type II; TGFR-2; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TbetaR-II

For Research Use Only. Not for use in diagnostic procedures.

One 96-Well Plate

Store at 4 degree C.

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of TGFBR2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9500586 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the TGF beta Receptor II (TGFBR2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TGFBR2. The ELISA analytical biochemical technique of the MBS9500586 kit is based on TGFBR2 antibody-TGFBR2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TGFBR2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TGFBR2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Cell Based ELISA Kit

64568

transforming growth factor beta receptor 2

TGF-beta receptor type-2

TGF-beta receptor type-2

TGFR-2; TGF-beta receptor type II; TbetaR-II??[Similar Products]

The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Aug 2017]

TGFBR2: a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Binds to DAXX. Defects can cause esophageal cancer.

Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type2 subfamily

Chromosomal Location of Human Ortholog: 3p24.1

Cellular Component: caveola; cytosol; external side of plasma membrane; integral component of membrane; membrane raft; plasma membrane; receptor complex; transforming growth factor beta receptor complex

Molecular Function: ATP binding; glycosaminoglycan binding; metal ion binding; mitogen-activated protein kinase kinase kinase binding; protein binding; signal transducer, downstream of receptor, with serine/threonine kinase activity; SMAD binding; transforming growth factor beta binding; transforming growth factor beta receptor activity, type II; transforming growth factor beta-activated receptor activity; transmembrane receptor protein serine/threonine kinase activity; type I transforming growth factor beta receptor binding

Biological Process: activation of protein kinase activity; aging; apoptosis; atrioventricular valve morphogenesis; blood vessel development; brain development; branching involved in blood vessel morphogenesis; cardiac left ventricle morphogenesis; cell proliferation involved in endocardial cushion morphogenesis; common-partner SMAD protein phosphorylation; embryo implantation; embryonic cranial skeleton morphogenesis; embryonic hemopoiesis; endocardial cushion fusion; gastrulation; growth plate cartilage chondrocyte growth; gut development; heart development; heart looping; in utero embryonic development; inferior endocardial cushion morphogenesis; lens development in camera-type eye; membranous septum morphogenesis; myeloid dendritic cell differentiation; negative regulation of cardiac muscle cell proliferation; negative regulation of transforming growth factor beta receptor signaling pathway; Notch signaling pathway; organ regeneration; outflow tract morphogenesis; outflow tract septum morphogenesis; palate development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of angiogenesis; positive regulation of B cell tolerance induction; positive regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of cell proliferation; positive regulation of epithelial cell migration; positive regulation of epithelial to mesenchymal transition; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; positive regulation of mesenchymal cell proliferation; positive regulation of NK T cell differentiation; positive regulation of reactive oxygen species metabolic process; positive regulation of skeletal muscle tissue regeneration; positive regulation of smooth muscle cell proliferation; positive regulation of T cell tolerance induction; positive regulation of tolerance induction to self antigen; protein amino acid phosphorylation; receptor-mediated endocytosis; regulation of cell proliferation; regulation of gene expression; response to drug; response to estrogen; response to glucose stimulus; response to hypoxia; response to mechanical stimulus; response to nutrient; response to steroid hormone; smoothened signaling pathway; superior endocardial cushion morphogenesis; transforming growth factor beta receptor signaling pathway; tricuspid valve morphogenesis; vasculogenesis; wound healing

Disease: Colorectal Cancer, Hereditary Nonpolyposis, Type 6; Esophageal Cancer; Loeys-dietz Syndrome 2

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.