MNX1; Homeo box HB9; Homeobox HB9; Homeobox protein HB9; HOXHB9; HB9; SCRA1; HLXB9

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

MNX1 Antibody detects endogenous levels of total MNX1

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1.0mg/mL (lot specific)

Store at -20 degree C

Small volumes of anti-MNX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Total protein Ab

Western Blot (WB)

Western Blot: 1:1000-3000

Western blot analysis MNX1 using LOVO whole cell lysates

20,553 Da

motor neuron and pancreas homeobox 1

motor neuron and pancreas homeobox protein 1

Motor neuron and pancreas homeobox protein 1

HLXB9??[Similar Products]

MNX1_HUMAN

This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

MNX1: Putative transcription factor involved in pancreas development and function. Defects in MNX1 are a cause of Currarino syndrome (CURRAS). The triad of a presacral tumor, sacral agenesis and anorectal malformation constitutes the Currarino syndrome which is caused by dorsal-ventral patterning defects during embryonic development. The syndrome occurs in the majority of patients as an autosomal dominant trait.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 7q36

Cellular Component: cytoplasm; nucleolus; nucleus

Molecular Function: transcription factor activity

Biological Process: anatomical structure morphogenesis; endocrine pancreas development; humoral immune response; neurite morphogenesis; regulation of transcription from RNA polymerase II promoter; spinal cord motor neuron cell fate specification

Disease: Currarino Syndrome

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