For Research Use Only. Not for use in diagnostic procedures.

Lyophilized powder

Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.

Small volumes of MNX1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This is a synthetic peptide designed for use in combination with anti-MNX1 antibody made

Target Description: MNX1 contains 1 homeobox DNA-binding domain. MNX1 is a putative transcription factor involved in pancreas development and function. Defects in MNX1 are a cause of Currarino syndrome.

Peptide

Western Blot (WB)

40kDa

motor neuron and pancreas homeobox 1

motor neuron and pancreas homeobox protein 1

Motor neuron and pancreas homeobox protein 1

HLXB9??[Similar Products]

MNX1_HUMAN

This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

MNX1: Putative transcription factor involved in pancreas development and function. Defects in MNX1 are a cause of Currarino syndrome (CURRAS). The triad of a presacral tumor, sacral agenesis and anorectal malformation constitutes the Currarino syndrome which is caused by dorsal-ventral patterning defects during embryonic development. The syndrome occurs in the majority of patients as an autosomal dominant trait.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 7q36

Cellular Component: nucleus

Molecular Function: sequence-specific DNA binding; transcription factor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; anatomical structure morphogenesis; transcription, DNA-dependent; spinal cord motor neuron cell fate specification; neuron migration; nerve development; motor axon guidance; endocrine pancreas development; dorsoventral neural tube patterning; humoral immune response; post-embryonic development

Disease: Currarino Syndrome

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