Product Name
C8A, cDNA Clone
Full Product Name
C8A cDNA Clone
Product Gene Name
C8A cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgtttgctg ttgttttctt catcttgtct ttgatgactt gtcagcctgg ggtaactgca caggagaagg tgaaccagag agtaagacgg gcagctacac ccgcagcagt tacctgccag ctgagcaact ggtcagagtg gacagattgc tttccgtgcc aggacaaaaa gtaccgacac cggagcctct tgcagccaaa caagtttggg ggaaccatct gcagtggtga catctgggat caagccagct gctccagttc tacaacttgt gtaaggaaag cacagtgtgg acaggatttc cagtgtaagg agacaggtcg ctgcctgaaa cgccaccttg tgtgtaatgg agaccaggac tgccttgatg gctctgatga ggacgactgt gaagatgtca gggccattga cgaagactgc agccagtatg aaccaattcc aggatcacag aaggcagcct tggggtacaa tatcctgacc caggaagatg ctcagagtgt gtacgatgcc agttattatg ggggccagtg tgagacggta tacaatgggg aatggaggga gcttcgatat gactccacct gtgaacgtct ctactatgga gatgatgaga aatactttcg gaaaccctac aactttctga agtaccactt tgaagccctg gcagatactg gaatctcctc agagttttat gataatgcaa atgaccttct ttccaaagtt aaaaaagaca agtctgactc atttggagtg accatcggca taggcccagc cggcagccct ttattggtgg gtgtaggtgt atcccactca caagacactt cattcttgaa cgaattaaac aagtataatg agaagaaatt cattttcaca agaatcttca caaaggtgca gactgcacat tttaagatga ggaaggatga cattatgctg gatgaaggaa tgctgcagtc attaatggag cttccagatc agtacaatta tggcatgtat gccaagttca tcaatgacta tggcacccat tacatcacat ctggatccat gggtggcatt tatgaatata tcctggtgat tgacaaagca aaaatggaat cccttggtat taccagcaga gatatcacga catgttttgg aggctccttg ggcattcaat atgaagacaa aataaatgtt ggtggaggtt tatcaggaga ccattgtaaa aaatttggag gtggcaaaac tgaaagggcc aggaaggcca tggctgtgga agacattatt tctcgggtgc gaggtggcag ttctggctgg agcggtggct tggcacagaa caggagcacc attacatacc gttcctgggg gaggtcatta aagtataatc ctgttgttat cgattttgag atgcagccta tccacgaggt gctgcggcac acaagcctgg ggcctctgga ggccaagcgc cagaacctgc gccgcgcctt ggaccagtat ctgatggaat tcaatgcctg ccgatgtggg ccttgcttca acaatggggt gcccatcctc gagggcacca gctgcaggtg ccagtgccgc ctgggtagct tgggtgctgc ctgtgagcaa acacagacag aaggagccaa agcagatggg agctggagtt gctggagctc ctggtctgta tgcagagcag gcatccagga aaggagaaga gagtgtgaca atccagcacc tcagaatgga ggggcctcgt gtccagggcg gaaagtacag acgcaggctt gctga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of C8A cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for C8A. It may not necessarily be applicable to this product.
NCBI Accession #
BC132911
[Other Products]
UniProt Secondary Accession #
Q13668; Q9H130; A2RUI4; A2RUI5[Other Products]
UniProt Related Accession #
P07357[Other Products]
Molecular Weight
65,163 Da
NCBI Official Full Name
Homo sapiens complement component 8, alpha polypeptide, mRNA
NCBI Official Synonym Full Names
complement C8 alpha chain
NCBI Official Symbol
C8A??[Similar Products]
NCBI Protein Information
complement component C8 alpha chain
UniProt Protein Name
Complement component C8 alpha chain
UniProt Synonym Protein Names
Complement component 8 subunit alpha
Protein Family
Complement component
UniProt Gene Name
C8A??[Similar Products]
UniProt Entry Name
CO8A_HUMAN
NCBI Summary for C8A
C8 is a component of the complement system and contains three polypeptides, alpha, beta and gamma. This gene encodes the alpha subunit of C8. C8 participates in the formation of the membrane attack complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause complement C8 alpha-gamma deficiency. [provided by RefSeq, Nov 2008]
UniProt Comments for C8A
C8A: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself. Defects in C8A are a cause of complement component 8 deficiency type 1 (C8D1). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.
Protein type: Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1p32
Cellular Component: extracellular region; extracellular space; membrane; membrane attack complex
Biological Process: complement activation; immune response; regulation of complement activation
Disease: Complement Component 8 Deficiency, Type I
Research Articles on C8A
1. C8 alpha and C8 beta have correspondingly similar roles in MAC-mediated lysis of erythrocytes and bacterial killing. C8 gamma is not required for complement-mediated killing of Gram-negative bacteria.
Precautions
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Disclaimer
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