Full Product Name
C8B Polyclonal Antibody
Product Synonym Names
C82
Product Gene Name
anti-C8B antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purification
Immunogen
Recombinant protein of human C8B
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-130999
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-C8B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-C8B antibody
Western Blot (WB)
Application Notes for anti-C8B antibody
WB: 1:500 - 1:2000
Western Blot (WB) of anti-C8B antibody
Western blot analysis of extract of various cells, using C8B antibody.
NCBI/Uniprot data below describe general gene information for C8B. It may not necessarily be applicable to this product.
NCBI GenBank Nucleotide #
NM_001278544.1
[Other Products]
UniProt Secondary Accession #
A1L4K7[Other Products]
UniProt Related Accession #
P07358[Other Products]
NCBI Official Full Name
complement component C8 beta chain isoform 3
NCBI Official Synonym Full Names
complement C8 beta chain
NCBI Official Symbol
C8B??[Similar Products]
NCBI Official Synonym Symbols
C82
??[Similar Products]
NCBI Protein Information
complement component C8 beta chain
UniProt Protein Name
Complement component C8 beta chain
UniProt Synonym Protein Names
Complement component 8 subunit beta
Protein Family
Complement component
UniProt Gene Name
C8B??[Similar Products]
UniProt Entry Name
CO8B_HUMAN
NCBI Summary for C8B
This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein mediates the interaction of C8 with the C5b-7 membrane attack complex precursor. In humans deficiency of this protein is associated with increased risk of meningococcal infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
UniProt Comments for C8B
C8B: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Defects in C8B are a cause of complement component 8 deficiency type 2 (C8D2). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1p32.2
Cellular Component: extracellular region; membrane
Biological Process: complement activation; immune response; regulation of complement activation
Disease: Complement Component 8 Deficiency, Type Ii
Research Articles on C8B
1. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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