Full Product Name
C8B Antibody
Product Synonym Names
C8B; Complement component C8 beta chain; Complement component 8 subunit beta
Product Gene Name
anti-C8B antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P07358
Species Reactivity
Human, Rat
Specificity
C8B Antibody detects endogenous levels of C8B protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human C8B.
Preparation and Storage
Store at -20 degree C for 1 year.
Other Notes
Small volumes of anti-C8B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-C8B antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-C8B antibody
WB: 1:500~1:2000
ELISA: 1:10000
NCBI/Uniprot data below describe general gene information for C8B. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000057.2
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NCBI GenBank Nucleotide #
NM_000066.3
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UniProt Primary Accession #
P07358
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UniProt Secondary Accession #
A1L4K7[Other Products]
UniProt Related Accession #
P07358[Other Products]
NCBI Official Full Name
complement component C8 beta chain isoform 1 preproprotein
NCBI Official Synonym Full Names
complement C8 beta chain
NCBI Official Symbol
C8B??[Similar Products]
NCBI Official Synonym Symbols
C82
??[Similar Products]
NCBI Protein Information
complement component C8 beta chain
UniProt Protein Name
Complement component C8 beta chain
UniProt Synonym Protein Names
Complement component 8 subunit beta
Protein Family
Complement component
UniProt Gene Name
C8B??[Similar Products]
NCBI Summary for C8B
This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein mediates the interaction of C8 with the C5b-7 membrane attack complex precursor. In humans deficiency of this protein is associated with increased risk of meningococcal infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
UniProt Comments for C8B
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
Research Articles on C8B
1. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
