Product Name
C8B, cDNA Clone
Full Product Name
C8B cDNA Clone
Product Gene Name
C8B cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgaagaatt ccaggacatg ggcttggagg gcgccggtgg agctatttct tctctgtgct gccctgggct gtctcagttt gcctggctcc agaggtgaaa ggccacattc ctttgggtca aatgcagtca acaagagctt tgctaagagc agacagatgc ggagtgtgga tgttaccctg atgcccattg attgtgagct gtctagttgg tcctcttgga ccacatgtga cccctgtcag aagaaaaggt acaggtatgc ctacttgctc cagccctctc agttccatgg ggaaccgtgc aacttctctg acaaggaagt cgaagactgt gttaccaaca gaccatgcag aagtcaagtg cgatgtgaag gctttgtgtg tgcacagaca ggaaggtgtg taaaccgcag acttctttgc aatggggaca atgactgtgg agaccagtca gatgaagcaa actgtagaag gatttataaa aaatgtcagc atgaaatgga ccaatactgg ggaattggca gtctggccag tgggataaat ttgttcacaa acagttttga gggcccagtt cttgatcaca ggtattatgc aggtggatgc tccccgcatt acatcctgaa cacgaggttt aggaagccct acaatgtgga aagctacacg ccacagaccc aaggcaaata cgaattcata ttaaaagagt atgaatcata ctcagatttt gaacgcaatg tcacagagaa aatggcaagc aagtctggtt tcagttttgg ttttaaaata cctggaatat ttgaacttgg catcagtagt caaagtgatc gaggcaaaca ctatattagg agaaccaaac gattctctca tactaaaagc gtatttctgc atgcacgctc tgaccttgaa gtagcacatt acaagctgaa acccagaagc ctcatgctcc attacgagtt ccttcagaga gttaagcggc tgcccctgga gtacagctac ggggaataca gagatctctt ccgtgatttt gggacccact acatcacaga ggctgtgctt gggggcattt atgaatacac cctcgttatg aacaaagagg ccatggagag aggagattat actcttaaca acgtccatgc ctgtgccaaa aatgatttta aaattggtgg tgccattgaa gaggtctacg tcagtctggg tgtgtctgta ggcaaatgca gaggtattct gaatgaaata aaagacagaa acaagaggga caccatggtg gaggacttgg tggtcctggt acgaggaggg gcaagtgagc acatcaccac cctggcatac caggagctgc cgacggcgga cctgatgcag gagtggggag acgctgtgca gtacaaccca gccatcatca aagttaaggt ggagcctctg tatgaactag tgacagccac agattttgcc tattccagca cagtgaggca gaacatgaag caggcactgg aggagttcca gaaggaagtt agttcctgcc actgtgctcc ctgccaagga aatggagtcc ctgtcctgaa aggatcacgc tgtgactgca tctgtcctgt tggatcccaa ggcctagcct gtgaggtctc ctatcggaag aataccccca ttgatgggaa gtggaattgc tggtcaaatt ggtcttcatg ctctggaaga cgtaagacaa gacaaaggca gtgtaacaat ccacctcctc aaaatggggg tagcccctgt tcaggccctg cttcagaaac acttgactgc tcctag
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of C8B cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for C8B. It may not necessarily be applicable to this product.
NCBI Accession #
BC130575
[Other Products]
UniProt Secondary Accession #
A1L4K7[Other Products]
UniProt Related Accession #
P07358[Other Products]
Molecular Weight
67,047 Da
NCBI Official Full Name
Homo sapiens complement component 8, beta polypeptide, mRNA
NCBI Official Synonym Full Names
complement C8 beta chain
NCBI Official Symbol
C8B??[Similar Products]
NCBI Official Synonym Symbols
C82
??[Similar Products]
NCBI Protein Information
complement component C8 beta chain
UniProt Protein Name
Complement component C8 beta chain
UniProt Synonym Protein Names
Complement component 8 subunit beta
Protein Family
Complement component
UniProt Gene Name
C8B??[Similar Products]
UniProt Entry Name
CO8B_HUMAN
NCBI Summary for C8B
This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein mediates the interaction of C8 with the C5b-7 membrane attack complex precursor. In humans deficiency of this protein is associated with increased risk of meningococcal infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
UniProt Comments for C8B
C8B: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Defects in C8B are a cause of complement component 8 deficiency type 2 (C8D2). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1p32.2
Cellular Component: extracellular region; membrane
Biological Process: complement activation; immune response; regulation of complement activation
Disease: Complement Component 8 Deficiency, Type Ii
Research Articles on C8B
1. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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