Product Name
Lamin A,C (lmna), Monoclonal Antibody
Full Product Name
Lamin A,C
Product Synonym Names
Anti -Lamin A,C
Product Gene Name
anti-lmna antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P11048
Species Reactivity
Bovine, Canine, Hamster, Human, Mouse, Rat, Sheep
Specificity
Recognizes lamin A and C. Recognizes an epitope between aa319-566. Species Crossreactivity: human, rat, mouse, bovine, canine, sheep and hamster.
Purity/Purification
Purified
Purified culture supernatant.
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide, before the addition of glycerol to 40%.
Immunogen
Lamin purified from rat liver.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-lmna antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-lmna antibody
Nuclear lamins form a network of filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished: A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Type A lamins comprise a set of three proteins arising from the same gene by alternative splicing: lamins A, C, and Adel 10. B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Mutations in A-lamins give rise to a range of genetic disorders, including autosomal dominant Emery-Dreifuss muscular dystrophy (AD-EDMD), dilated cardiomyopathy and Dunnigan-type familial partial lipodystrophy. Aberrant expression patterns of nuclear lamins have been described in various types of cancer depending on the subtype of cancer, its aggressiveness, proliferative capacity and degree of differentiation. In general, the expression of A-type lamins (lamins A and C) has been correlated with a non-proliferating, differentiated state of cells and tissues. Lamins A and C, the products of the LMNA gene, are nuclear intermediate filament proteins and are the major structural components of the lamina network that underlies and supports the nuclear envelope. Expression of A-lamin coincides with cell differentiation and may be related protein's abnormal expression and organization in neoplastic tissues and cells.
Product Categories/Family for anti-lmna antibody
Antibodies; Abs to Nuclear Proteins
Applications Tested/Suitable for anti-lmna antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
Application Notes for anti-lmna antibody
Suitable for use in Immunoblot, Immunocytochemistry and Immunohistochemistry.
Dilution: Immunoblot: 1:50-1:500
Immunocytochemistry: 1:50-1:100 (Cells fixed with methanol/acetone).
Immunohistochemistry: 1:50-1:100 (Frozen tissue sections).
Optimal dilution determined by the researcher.
NCBI/Uniprot data below describe general gene information for lmna. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001095210.1
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NCBI GenBank Nucleotide #
NM_001101740.1
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UniProt Primary Accession #
P11048
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UniProt Related Accession #
P11048; AAB23219[Other Products]
Molecular Weight
74,919 Da[Similar Products]
NCBI Official Full Name
lamin-A
NCBI Official Synonym Full Names
lamin A/C<
NCBI Official Symbol
lmna??[Similar Products]
NCBI Official Synonym Symbols
lmna-A
??[Similar Products]
NCBI Protein Information
lamin-A
UniProt Protein Name
Lamin-A
UniProt Gene Name
lmna??[Similar Products]
UniProt Entry Name
LMNA_XENLA
UniProt Comments for lmna
Function: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
Subcellular location: Nucleus.
Miscellaneous: There are at least five different lamins in Xenopus: the somatic lamins L(I), L(II), and A; the oocyte germinal vesicle lamin L(III); and the male germ cells lamin l(IV).
Sequence similarities: Belongs to the intermediate filament family.
Research Articles on lmna
1. Ectopic expression of prelamin A in early Xenopus embryos induces apoptosis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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