Coagulation factor XI; FXI; Plasma thromboplastin antecedent; PTA; F11; 3.4.21.27

For Research Use Only. Not for use in diagnostic procedures.

Store at 4 degree C

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Small volumes of F11 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9426193 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Coagulation factor XI (F11) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing F11. The ELISA analytical biochemical technique of the MBS9426193 kit is based on F11 antibody-F11 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect F11 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, F11. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

69,789 Da

coagulation factor XI

coagulation factor XI

Coagulation factor XI

FXI; PTA??[Similar Products]

This gene encodes a glycoprotein coagulation factor that plays an important role in intrinsic pathway of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that can be activated by coagulation factor XIIa, thrombin or factor XIa to generate active factor XIa protease. Mice lacking the encoded protein display a survival advantage during peritoneal sepsis and resist inflammation and bacterial accumulation upon infection with Listeria. [provided by RefSeq, Apr 2015]

F11: Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. Defects in F11 are the cause of factor XI deficiency (FA11D); also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate. Belongs to the peptidase S1 family. Plasma kallikrein subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.21.27; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8 B1.1|8 25.14 cM

Cellular Component: extracellular space

Biological Process: blood coagulation; plasminogen activation; positive regulation of fibrinolysis; regulation of blood coagulation

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