Motor neuron and pancreas homeobox protein 1; Homeobox protein HB9; MNX1; HLXB9

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This MNX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 242-271 amino acids from the Central region of human MNX1.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-MNX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a nuclear protein, which contains a
homeobox domain and is a transcription factor. Mutations in this
gene result in Currarino syndrome, an autosomic dominant congenital
malformation. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq].

Developmental Biology; Neuroscience; Signal Transduction

Western Blot (WB), ELISA (EIA)

WB~~1:1000

MNX1 Antibody (Center) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the MNX1 antibody detected the MNX1 protein (arrow).

40569

motor neuron and pancreas homeobox 1

motor neuron and pancreas homeobox protein 1

Motor neuron and pancreas homeobox protein 1

HLXB9??[Similar Products]

MNX1_HUMAN

This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

MNX1: Putative transcription factor involved in pancreas development and function. Defects in MNX1 are a cause of Currarino syndrome (CURRAS). The triad of a presacral tumor, sacral agenesis and anorectal malformation constitutes the Currarino syndrome which is caused by dorsal-ventral patterning defects during embryonic development. The syndrome occurs in the majority of patients as an autosomal dominant trait.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 7q36

Cellular Component: nucleus

Molecular Function: sequence-specific DNA binding; transcription factor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; anatomical structure morphogenesis; transcription, DNA-dependent; spinal cord motor neuron cell fate specification; neuron migration; nerve development; motor axon guidance; endocrine pancreas development; humoral immune response; dorsoventral neural tube patterning; post-embryonic development

Disease: Currarino Syndrome

Turgut, M. Acta Neurochir (Wien) 152(6):1083-1084(2010)
Garcia-Barcelo, M.M., et al. J. Pediatr. Surg. 44(10):1892-1898(2009)
Park, J., et al. Cancer Genet. Cytogenet. 191(2):102-105(2009)
Ballabio, E., et al. Leukemia 23(6):1179-1182(2009)
Taketani, T., et al. Cancer Genet. Cytogenet. 186(2):115-119(2008)

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.