Product Name
ASCL1, Blocking Peptide
Full Product Name
ASCL1 Immunizing Peptide
Product Gene Name
ASCL1 blocking peptide
[Similar Products]
ASCL1 peptide (MBS428805) is used for blocking the activity of ASCL1 antibody (MBS423773)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
C-HKSAPKQV KRQRS
3D Structure
ModBase 3D Structure for P50553
Species Reactivity
Mouse, Rat
Expected from sequence similarity: Human, Cow, Dog
Form/Format
100ug of Lyophilised peptide, formulation 5pmol/ul in 5% (v/v) acetonitrile/H2O.
Reconstitution
Reconstitute pellet in distilled water where required.
For Blocking studies, reconstitute pellet in 200ul distilled water to obtain a 0.5mg/ml peptide solution.
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of ASCL1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ASCL1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_004307.2
[Other Products]
NCBI GenBank Nucleotide #
NM_004316.3
[Other Products]
UniProt Primary Accession #
P50553
[Other Products]
UniProt Secondary Accession #
Q9BQ30; A8K3C4[Other Products]
UniProt Related Accession #
P50553[Other Products]
Molecular Weight
25,454 Da
NCBI Official Full Name
achaete-scute homolog 1
NCBI Official Synonym Full Names
achaete-scute family bHLH transcription factor 1
NCBI Official Symbol
ASCL1??[Similar Products]
NCBI Official Synonym Symbols
ASH1; HASH1; MASH1; bHLHa46
??[Similar Products]
NCBI Protein Information
achaete-scute homolog 1
UniProt Protein Name
Achaete-scute homolog 1
UniProt Synonym Protein Names
Class A basic helix-loop-helix protein 46
Protein Family
Achaete-scute
UniProt Gene Name
ASCL1??[Similar Products]
UniProt Synonym Gene Names
bHLHa46??[Similar Products]
NCBI Summary for ASCL1
This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq, Jul 2008]
UniProt Comments for ASCL1
Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation.
Research Articles on ASCL1
1. a large subset of patient-derived glioblastoma stem cells (GSCs) express high levels of Achaete-scute homolog 1 (ASCL1), a proneural transcription factor involved in normal neurogenesis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
