Achaete-scute homolog 1 (ASH-1) (hASH1) (Class A basic helix-loop-helix protein 46) (bHLHa46)

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Affinity Purification

1mg/mL (lot specific)

Store at -20 degree C. Avoid freeze / thaw cycles.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-ASCL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases.

Immunohistochemistry (IHC) Paraffin, ELISA (EIA)

IHC: 1:50-200
ELISA: 1:10000-20000

Immunohistochemistry of paraffin-embedded Human lung tissue using ASCL1 Polyclonal Antibody at dilution of 1:200.

Immunohistochemistry of paraffin-embedded Human lung tissue using ASCL1 Polyclonal Antibody at dilution of 1:200.

25,454 Da

achaete-scute family bHLH transcription factor 1

achaete-scute homolog 1

Achaete-scute homolog 1

bHLHa46??[Similar Products]

This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq, Jul 2008]

ASCL1: Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5'-CANNTG-3').

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q23.2

Cellular Component: cell soma; nucleus; RNA polymerase II transcription factor complex

Molecular Function: bHLH transcription factor binding; chromatin binding; DNA binding; DNA binding transcription factor activity; protein binding; protein homodimerization activity

Biological Process: cell maturation; central nervous system neuron development; cerebral cortex development; cerebral cortex GABAergic interneuron differentiation; commitment of a neuronal cell to a specific type of neuron in the forebrain; musculoskeletal movement, spinal reflex action; negative regulation of apoptosis; negative regulation of neuron differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neuroblast fate determination; neuroblast proliferation; neurogenesis; neuron development; neuron differentiation; neuron fate commitment; neuron fate specification; neuron migration; noradrenergic neuron development; noradrenergic neuron fate commitment; Notch signaling pathway; olfactory pit development; oligodendrocyte development; positive regulation of cell cycle; positive regulation of neural precursor cell proliferation; positive regulation of neuron apoptotic process; positive regulation of neuron differentiation; positive regulation of Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; regulation of epithelial cell differentiation; regulation of gene expression; regulation of mitotic cell cycle; regulation of timing of subpallium neuron differentiation; response to folic acid; response to lithium ion; response to retinoic acid; spinal cord association neuron differentiation; spinal cord oligodendrocyte cell fate specification; subpallium neuron fate commitment; sympathetic nervous system development; transcription, DNA-dependent; vestibular nucleus development

Disease: Central Hypoventilation Syndrome, Congenital

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