Full Product Name
C8B, CT (C8B, Complement component C8 beta chain, Complement component 8 subunit beta)
Product Synonym Names
Anti -C8B, CT (C8B, Complement component C8 beta chain, Complement component 8 subunit beta)
Product Gene Name
anti-C8B antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_000001.10 (57394883..57433213, complement). Location: 1p32.2
3D Structure
ModBase 3D Structure for P07358
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Immunogen
C8B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 393-422 amino acids from the C-terminal region of human C8B.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-C8B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-C8B antibody
C8 beta is one of the three subunits that comprise the component 8 (C8) of the complement system. C8 participates in the formation of Membrane Attack Complex that results in the lysis of cells. Patients with C8B deficiency are prone to bacteria infection.
Product Categories/Family for anti-C8B antibody
Antibodies; Abs to Complement
Applications Tested/Suitable for anti-C8B antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-C8B antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
NCBI/Uniprot data below describe general gene information for C8B. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000057.2
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NCBI GenBank Nucleotide #
NM_000066.3
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UniProt Primary Accession #
P07358
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UniProt Secondary Accession #
A1L4K7[Other Products]
UniProt Related Accession #
P07358[Other Products]
Molecular Weight
67,047 Da[Similar Products]
NCBI Official Full Name
complement component C8 beta chain isoform 1 preproprotein
NCBI Official Synonym Full Names
complement component 8, beta polypeptide
NCBI Official Symbol
C8B??[Similar Products]
NCBI Official Synonym Symbols
C82
??[Similar Products]
NCBI Protein Information
complement component C8 beta chain; complement component 8 subunit beta
UniProt Protein Name
Complement component C8 beta chain
UniProt Synonym Protein Names
Complement component 8 subunit beta
Protein Family
Complement component
UniProt Gene Name
C8B??[Similar Products]
UniProt Entry Name
CO8B_HUMAN
NCBI Summary for C8B
This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein mediates the interaction of C8 with the C5b-7 membrane attack complex precursor. In humans deficiency of this protein is associated with increased risk of meningococcal infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
UniProt Comments for C8B
Function: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
Subunit structure: Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded. Component of the membrane attack complex (MAC). MAC assembly is initiated by protelytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9. Ref.8 Ref.12
Subcellular location: Secreted.
Post-translational modification: N-glycosylated; contains one or two bound glycans. Not O-glycosylated. Ref.1 Ref.9
Polymorphism: The sequence shown is that of allotype C8B B.
Involvement in disease: Complement component 8 deficiency, 2 (C8D2) [MIM:613789]: A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
Sequence similarities: Belongs to the complement C6/C7/C8/C9 family.Contains 1 EGF-like domain.Contains 1 LDL-receptor class A domain.Contains 1 MACPF domain.Contains 2 TSP type-1 domains.
Research Articles on C8B
1. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Precautions
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Disclaimer
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