Product Name
AMER1, Blocking Peptide
Full Product Name
AMER1 Peptide - middle region
Product Gene Name
AMER1 blocking peptide
[Similar Products]
Product Synonym Gene Name
WTX; OSCS; FAM123B; AMER1[Similar Products]
AMER1 peptide (MBS3246194) is used for blocking the activity of AMER1 antibody (MBS3221460)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
Synthetic peptide located within the following region: CLPRDSYSGD ALYEFYEPDD SLENSPPGDD CLYDLHGRSS EMFDPFLNFE
3D Structure
ModBase 3D Structure for Q5JTC6
Form/Format
Lyophilized powder
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of AMER1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
AMER1 blocking peptide
The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS).
Product Categories/Family for AMER1 blocking peptide
Peptide
NCBI/Uniprot data below describe general gene information for AMER1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_689637.3
[Other Products]
NCBI GenBank Nucleotide #
NM_152424.3
[Other Products]
UniProt Primary Accession #
Q5JTC6
[Other Products]
UniProt Related Accession #
Q5JTC6[Other Products]
NCBI Official Full Name
APC membrane recruitment protein 1
NCBI Official Synonym Full Names
APC membrane recruitment protein 1
NCBI Official Symbol
AMER1??[Similar Products]
NCBI Official Synonym Symbols
WTX; OSCS; FAM123B
??[Similar Products]
NCBI Protein Information
APC membrane recruitment protein 1
UniProt Protein Name
APC membrane recruitment protein 1
UniProt Synonym Protein Names
Protein FAM123B; Wilms tumor gene on the X chromosome protein
Protein Family
APC membrane recruitment protein
UniProt Gene Name
AMER1??[Similar Products]
UniProt Synonym Gene Names
FAM123B; WTX; Amer1??[Similar Products]
UniProt Entry Name
AMER1_HUMAN
NCBI Summary for AMER1
The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS). [provided by RefSeq, May 2010]
UniProt Comments for AMER1
WTX: a peripheral membrane protein on the cytoplasmic side that shuttles between nucleus and cytoplasm. Detected in nuclear paraspeckles that are found close to splicing speckles. Enhances trancription activation by WT1. Promotes CTNNB1 ubiquitination and degradation. Antagonizes Wnt and CTNNB1 signaling. Inactivated in approximately one-third of Wilms tumors. Detected in fetal and ***** kidney, brain and spleen. Involved in kidney development. Interacts with CTNNB1, AXIN1, KEAP1, APC and BTRC. Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes containing BTRC and/or FBXW11. Identified in a complex containing CTNNB1, APC, AXIN1 and AXIN2. Two alternatively spliced human isoforms have been reported.
Chromosomal Location of Human Ortholog: Xq11.2
Cellular Component: plasma membrane; nucleus; cytosol
Molecular Function: protein binding; phosphatidylinositol-4,5-bisphosphate binding; beta-catenin binding
Biological Process: Wnt receptor signaling pathway
Disease: Osteopathia Striata With Cranial Sclerosis
Research Articles on AMER1
1. A novel heterozygous frameshift mutation in AMER1 was identified in a patient with osteopathia striata with cranial sclerosis.
Precautions
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Disclaimer
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