Full Product Name
AMER1 Antibody - middle region
Product Gene Name
anti-AMER1 antibody
[Similar Products]
Product Synonym Gene Name
WTX; OSCS; FAM123B[Similar Products]
Antibody/Peptide Pairs
AMER1 peptide (MBS3246194) is used for blocking the activity of AMER1 antibody (MBS3221460)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: CLPRDSYSGD ALYEFYEPDD SLENSPPGDD CLYDLHGRSS EMFDPFLNFE
3D Structure
ModBase 3D Structure for Q5JTC6
Purity/Purification
Affinity purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human FAM123B
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-AMER1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AMER1 antibody
The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS).
Product Categories/Family for anti-AMER1 antibody
Polyclonal; Cancer; Transcription Regulation; DNA/RNA/Protein Interactions;
Applications Tested/Suitable for anti-AMER1 antibody
Western Blot (WB)
Western Blot (WB) of anti-AMER1 antibody
Host: Rabbit
Target Name: FAM123B
Sample Tissue: Human Lung Tumor lysates
Antibody Dilution: 1ug/ml
NCBI/Uniprot data below describe general gene information for AMER1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_689637.3
[Other Products]
NCBI GenBank Nucleotide #
NM_152424.3
[Other Products]
UniProt Primary Accession #
Q5JTC6
[Other Products]
UniProt Related Accession #
Q5JTC6[Other Products]
NCBI Official Full Name
APC membrane recruitment protein 1
NCBI Official Synonym Full Names
APC membrane recruitment protein 1
NCBI Official Symbol
AMER1??[Similar Products]
NCBI Official Synonym Symbols
WTX; OSCS; FAM123B
??[Similar Products]
NCBI Protein Information
APC membrane recruitment protein 1
UniProt Protein Name
APC membrane recruitment protein 1
UniProt Synonym Protein Names
Protein FAM123B; Wilms tumor gene on the X chromosome protein
Protein Family
APC membrane recruitment protein
UniProt Gene Name
AMER1??[Similar Products]
UniProt Synonym Gene Names
FAM123B; WTX; Amer1??[Similar Products]
UniProt Entry Name
AMER1_HUMAN
NCBI Summary for AMER1
The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS). [provided by RefSeq, May 2010]
UniProt Comments for AMER1
WTX: a peripheral membrane protein on the cytoplasmic side that shuttles between nucleus and cytoplasm. Detected in nuclear paraspeckles that are found close to splicing speckles. Enhances trancription activation by WT1. Promotes CTNNB1 ubiquitination and degradation. Antagonizes Wnt and CTNNB1 signaling. Inactivated in approximately one-third of Wilms tumors. Detected in fetal and ***** kidney, brain and spleen. Involved in kidney development. Interacts with CTNNB1, AXIN1, KEAP1, APC and BTRC. Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes containing BTRC and/or FBXW11. Identified in a complex containing CTNNB1, APC, AXIN1 and AXIN2. Two alternatively spliced human isoforms have been reported.
Chromosomal Location of Human Ortholog: Xq11.2
Cellular Component: plasma membrane; nucleus; cytosol
Molecular Function: protein binding; phosphatidylinositol-4,5-bisphosphate binding; beta-catenin binding
Biological Process: Wnt receptor signaling pathway
Disease: Osteopathia Striata With Cranial Sclerosis
Research Articles on AMER1
1. Data suggest that the aberrant upregulation of miR-20a/miR-106a as the reason of Wilms tumor gene on the X chromosome (WTX) loss in colorectal cancer (CRC) both in vivo and in vitro.
Precautions
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Disclaimer
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