Full Product Name
IHH Rabbit Polyclonal
Product Gene Name
anti-IHH antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Immunogen
Indian hedgehog homolog (Drosophila)
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-IHH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-IHH antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for IHH. It may not necessarily be applicable to this product.
NCBI Accession #
AKI71079.1
[Other Products]
UniProt Secondary Accession #
O43322; Q8N4B9; B9EGM5[Other Products]
UniProt Related Accession #
Q14623[Other Products]
Molecular Weight
45,251 Da
NCBI Official Full Name
IHH, partial
NCBI Official Synonym Full Names
indian hedgehog
NCBI Official Symbol
IHH??[Similar Products]
NCBI Official Synonym Symbols
BDA1; HHG2
??[Similar Products]
NCBI Protein Information
indian hedgehog protein
UniProt Protein Name
Indian hedgehog protein
UniProt Synonym Protein Names
HHG-2
Protein Family
Indian hedgehog protein
UniProt Gene Name
IHH??[Similar Products]
UniProt Synonym Gene Names
IHH??[Similar Products]
UniProt Entry Name
IHH_HUMAN
NCBI Summary for IHH
This gene encodes a member of the hedgehog family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including an N-terminal fragment that is involved in signaling. Hedgehog family proteins are essential secreted signaling molecules that regulate a variety of developmental processes including growth, patterning and morphogenesis. The protein encoded by this gene specifically plays a role in bone growth and differentiation. Mutations in this gene are the cause of brachydactyly type A1, which is characterized by shortening or malformation of the fingers and toes. Mutations in this gene are also the cause of acrocapitofemoral dysplasia. [provided by RefSeq, Nov 2015]
UniProt Comments for IHH
IHH: Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP). Expressed in embryonic lung, and in ***** kidney and liver. Belongs to the hedgehog family.
Chromosomal Location of Human Ortholog: 2q33-q35
Cellular Component: extracellular space; plasma membrane
Molecular Function: calcium ion binding; patched binding; peptidase activity
Biological Process: cartilage development; cell-cell signaling; embryonic digit morphogenesis; heart looping; intein-mediated protein splicing; maternal process involved in pregnancy; negative regulation of alpha-beta T cell differentiation; negative regulation of apoptosis; negative regulation of immature T cell proliferation in the thymus; negative regulation of signal transduction; negative regulation of T cell differentiation in the thymus; positive regulation of alpha-beta T cell differentiation; positive regulation of chondrocyte differentiation; positive regulation of epithelial cell proliferation; positive regulation of smoothened signaling pathway; positive regulation of T cell differentiation in the thymus; positive regulation of transcription from RNA polymerase II promoter; response to estradiol stimulus; skeletal development; smoothened signaling pathway
Disease: Acrocapitofemoral Dysplasia; Brachydactyly, Type A1
Research Articles on IHH
1. Studies indicate that the hedgehog (Hh) signaling pathway has become one of the most studied potential therapeutic targets in hematological malignancies.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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