Product Name
IHH, Blocking Peptide
Full Product Name
IHH Blocking Peptide (C-term)
Product Synonym Names
Indian hedgehog protein; IHH; HHG-2; Indian hedgehog protein N-product; Indian hedgehog protein C-product; IHH
Product Gene Name
IHH blocking peptide
[Similar Products]
IHH peptide (MBS9230127) is used for blocking the activity of IHH antibody (MBS9216769)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q14623
Specificity
The synthetic peptide sequence is selected from aa 248-261 of HUMAN IHH
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Indian hedgehog protein N-product: Cell membrane; Lipid-anchor; Extracellular side. Note: The N-terminal peptide remains associated with the cell surface. Cell membrane.
Tissue Location
Expressed in embryonic lung, and in ***** kidney and liver
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of IHH blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
IHH blocking peptide
Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity).
NCBI/Uniprot data below describe general gene information for IHH. It may not necessarily be applicable to this product.
NCBI Accession #
Q14623.4
[Other Products]
UniProt Primary Accession #
Q14623
[Other Products]
UniProt Secondary Accession #
O43322; Q8N4B9; B9EGM5[Other Products]
UniProt Related Accession #
Q14623[Other Products]
Molecular Weight
45,251 Da
NCBI Official Full Name
Indian hedgehog protein
NCBI Official Synonym Full Names
indian hedgehog
NCBI Official Symbol
IHH??[Similar Products]
NCBI Official Synonym Symbols
BDA1; HHG2
??[Similar Products]
NCBI Protein Information
indian hedgehog protein
UniProt Protein Name
Indian hedgehog protein
UniProt Synonym Protein Names
HHG-2
Protein Family
Indian hedgehog protein
UniProt Gene Name
IHH??[Similar Products]
UniProt Synonym Gene Names
IHH??[Similar Products]
UniProt Entry Name
IHH_HUMAN
NCBI Summary for IHH
This gene encodes a member of the hedgehog family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including an N-terminal fragment that is involved in signaling. Hedgehog family proteins are essential secreted signaling molecules that regulate a variety of developmental processes including growth, patterning and morphogenesis. The protein encoded by this gene specifically plays a role in bone growth and differentiation. Mutations in this gene are the cause of brachydactyly type A1, which is characterized by shortening or malformation of the fingers and toes. Mutations in this gene are also the cause of acrocapitofemoral dysplasia. [provided by RefSeq, Nov 2015]
UniProt Comments for IHH
IHH: Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP). Expressed in embryonic lung, and in ***** kidney and liver. Belongs to the hedgehog family.
Chromosomal Location of Human Ortholog: 2q33-q35
Cellular Component: plasma membrane
Molecular Function: calcium ion binding; patched binding
Biological Process: heart looping; negative regulation of alpha-beta T cell differentiation; negative regulation of immature T cell proliferation in the thymus; negative regulation of T cell differentiation in the thymus; positive regulation of alpha-beta T cell differentiation; positive regulation of smoothened signaling pathway; positive regulation of T cell differentiation in the thymus; skeletal development; smoothened signaling pathway
Disease: Acrocapitofemoral Dysplasia; Brachydactyly, Type A1
Research Articles on IHH
1. Studies indicate that the hedgehog (Hh) signaling pathway has become one of the most studied potential therapeutic targets in hematological malignancies.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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