Indian hedgehog

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This Ihh antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 169-200 amino acids from the C-terminal region of human Ihh.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Vial Concentration: 2 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-Q80XI9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Ihh (Indian hedgehog) is a critical and possibly direct regulator of joint development. In its absence, distribution and function of Gdf5-expressing interzone-associated cells are abnormal.

Western Blot (WB), ELISA (EIA)

WB~~1:1000

Western blot analysis of anti-Ihh Pab (RB10378) in HL60 cell line lysates (35ug/lane). Ihh (arrow) was detected using the purified Pab.

49445

Indian hedgehog

indian hedgehog protein

Hedgehog protein

Q80XI9_MOUSE

IHH: Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP). Expressed in embryonic lung, and in ***** kidney and liver. Belongs to the hedgehog family.

Cellular Component: proteinaceous extracellular matrix; membrane; plasma membrane; extracellular region

Molecular Function: peptidase activity; protein binding; hydrolase activity; metal ion binding; patched binding; calcium ion binding

Biological Process: vitelline membrane formation; proteoglycan metabolic process; multicellular organismal development; positive regulation of collagen biosynthetic process; cell maturation; cell fate specification; proteolysis; embryonic pattern specification; positive regulation of T cell differentiation in the thymus; smooth muscle development; cell-cell signaling; vasculature development; embryonic digestive tract morphogenesis; regulation of cell differentiation; regulation of growth; pancreas development; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of smoothened signaling pathway; cell communication; heart looping; cell differentiation; skeletal development; bone resorption; negative regulation of immature T cell proliferation in the thymus; smoothened signaling pathway; ossification; camera-type eye development; intein-mediated protein splicing; in utero embryonic development; multicellular organism growth; negative regulation of eye pigmentation; morphogenesis of a branching structure; negative regulation of T cell differentiation in the thymus; pattern specification process; negative regulation of signal transduction; patterning of blood vessels; osteoblast differentiation; negative regulation of cell differentiation; embryonic development; positive regulation of chondrocyte differentiation; cartilage development; neuron development; positive regulation of transcription from RNA polymerase II promoter; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; positive regulation of alpha-beta T cell differentiation; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; negative regulation of alpha-beta T cell differentiation

Kobayashi,T., Proc. Natl. Acad. Sci. U.S.A. 105 (6), 1949-1954 (2008)
Gat-Yablonski,G.,J. Pediatr. Endocrinol. Metab. 20 (11), 1215-1222 (2007)
Koyama,E., Ann. N. Y. Acad. Sci. 1116, 100-112 (2007)

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