Product Name
APC membrane recruitment protein 1 (FAM123B), Recombinant Protein
Full Product Name
Recombinant Human APC membrane recruitment protein 1 (FAM123B) , partial
Product Gene Name
FAM123B recombinant protein
[Similar Products]
Product Synonym Gene Name
FAM123B[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q5JTC6
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of FAM123B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for FAM123B. It may not necessarily be applicable to this product.
NCBI Accession #
NP_689637.3
[Other Products]
NCBI GenBank Nucleotide #
NM_152424.3
[Other Products]
UniProt Primary Accession #
Q5JTC6
[Other Products]
UniProt Secondary Accession #
Q8N885; A2IB86[Other Products]
UniProt Related Accession #
Q5JTC6[Other Products]
Molecular Weight
87,823 Da
NCBI Official Full Name
APC membrane recruitment protein 1
NCBI Official Synonym Full Names
APC membrane recruitment protein 1
NCBI Official Symbol
AMER1??[Similar Products]
NCBI Official Synonym Symbols
WTX; OSCS; FAM123B
??[Similar Products]
NCBI Protein Information
APC membrane recruitment protein 1
UniProt Protein Name
APC membrane recruitment protein 1
UniProt Synonym Protein Names
Protein FAM123B; Wilms tumor gene on the X chromosome protein
UniProt Gene Name
AMER1??[Similar Products]
UniProt Synonym Gene Names
FAM123B; WTX; Amer1??[Similar Products]
NCBI Summary for FAM123B
The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS). [provided by RefSeq, May 2010]
UniProt Comments for FAM123B
Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development.
Research Articles on FAM123B
1. Losses of AMER1 by other mechanisms apart from mutations.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
