Product Name
cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A), Protein
Full Product Name
cGMP-specific 3',5'-cyclic phosphodiesterase
Product Synonym Names
Pde5; cGMP-binding cGMP-specific phosphodiesterase; CGB-PDE
Product Gene Name
PDE5A protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
546-811aa
3D Structure
ModBase 3D Structure for O54735
Purity/Purification
>95% by SDS-PAGE
Endotoxin Level
<0.10 EU per 1 mug of the protein by the LAL method
Storage Buffer
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
Preparation and Storage
Store at -20 degree C.
Avoid repeated freezing and thawing.
Other Notes
Small volumes of PDE5A protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for PDE5A protein
ELISA (EIA), Western Blot (WB), Affinity Purification (AP), Protein Array
NCBI/Uniprot data below describe general gene information for PDE5A. It may not necessarily be applicable to this product.
NCBI Accession #
NP_598268.1
[Other Products]
NCBI GenBank Nucleotide #
NM_133584.1
[Other Products]
UniProt Primary Accession #
O54735
[Other Products]
UniProt Related Accession #
O54735[Other Products]
NCBI Official Full Name
cGMP-specific 3',5'-cyclic phosphodiesterase
NCBI Official Synonym Full Names
phosphodiesterase 5A
NCBI Official Symbol
Pde5a??[Similar Products]
NCBI Official Synonym Symbols
PDE5A2
??[Similar Products]
NCBI Protein Information
cGMP-specific 3',5'-cyclic phosphodiesterase
UniProt Protein Name
cGMP-specific 3',5'-cyclic phosphodiesterase
UniProt Synonym Protein Names
cGMP-binding cGMP-specific phosphodiesterase; CGB-PDE
Protein Family
cGMP-specific 3',5'-cyclic phosphodiesterase
UniProt Gene Name
Pde5a??[Similar Products]
UniProt Synonym Gene Names
Pde5; CGB-PDE??[Similar Products]
NCBI Summary for PDE5A
catalyzes the hydrolysis of cGMP to 5'-GMP; may regulate vascular relaxation; may be involved in establishment of cerebellar neural networks [RGD, Feb 2006]
UniProt Comments for PDE5A
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP.
Research Articles on PDE5A
1. Our data showed a significant and previously undocumented upregulation of PDE5 in both rat and human BPH.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
