IKK Gamma Antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Purified whole serum by affinity chromatography.

Liquid in phosphate buffered saline with 0.02% sodium azide, 50% glycerol.

Store at -20 degree C.
Storage in frost-free freezers is not recommended. This product should be stored undiluted.
Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of despatch

Small volumes of anti-IKBKG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Rabbit anti IKK gamma antibody recognizes IKK gamma, also known as NF-kappa-B essential modulator (NEMO), IKBKG and inhibitor of nuclear factor kappa-B kinase subunit gamma. IKK gamma is the regulatory subunit of the inhibitor of IkB kinase complex which activates NF-kappa-B resulting in expression of genes involved in inflammation, immunity, cell survival, and other pathways.

Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

IHC-Paraffin: 1:50-1:100
WB: 1:500-1:2000

Western blot analysis of cell and tissue lysates using Rabbit anti IKK gamma antibody

Immunohistochemistry of paraffin-embedded human liver cancer using Rabbit anti IKK gamma antibody at a dilution of 1/100

Immunohistochemistry of paraffin-embedded rat heart using Rabbit anti IKK gamma antibody

Immunohistochemistry of paraffin-embedded rat brain using Rabbit anti IKK gamma antibody

36,953 Da

inhibitor of nuclear factor kappa B kinase subunit gamma

NF-kappa-B essential modulator

NF-kappa-B essential modulator

FIP3; NEMO; NEMO; IKKAP1; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma??[Similar Products]

This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Mar 2016]

Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.

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