Full Product Name
CCDC6 Antibody
Product Synonym Names
D10S170; FLJ32286; H4; PTC; TPC; TST1
Product Gene Name
anti-CCDC6 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Immunogen
Fusion protein of CCDC6
Calculated Molecular Weight: 474aa; 53kd
Observed Molecular Weight: 53Kd
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CCDC6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CCDC6 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-CCDC6 antibody
WB: 1:1000-1:10000
Testing Data of anti-CCDC6 antibody
NCBI/Uniprot data below describe general gene information for CCDC6. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005427.2
[Other Products]
NCBI GenBank Nucleotide #
NM_005436.4
[Other Products]
UniProt Secondary Accession #
Q15250; Q6GSG7[Other Products]
UniProt Related Accession #
Q16204[Other Products]
Molecular Weight
53,291 Da
NCBI Official Full Name
coiled-coil domain-containing protein 6
NCBI Official Synonym Full Names
coiled-coil domain containing 6
NCBI Official Symbol
CCDC6??[Similar Products]
NCBI Official Synonym Symbols
H4; PTC; TPC; TST1; D10S170
??[Similar Products]
NCBI Protein Information
coiled-coil domain-containing protein 6; papillary thyroid carcinoma-encoded protein
UniProt Protein Name
Coiled-coil domain-containing protein 6
UniProt Synonym Protein Names
Papillary thyroid carcinoma-encoded protein; Protein H4
Protein Family
Coiled-coil domain-containing protein
UniProt Gene Name
CCDC6??[Similar Products]
UniProt Synonym Gene Names
D10S170; TST1??[Similar Products]
UniProt Entry Name
CCDC6_HUMAN
NCBI Summary for CCDC6
This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010]
UniProt Comments for CCDC6
CCDC6: Defects in CCDC6 are a cause of thyroid papillary carcinoma (TPC). TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. A chromosomal aberration involving CCDC6 is found in thyroid papillary carcinomas. Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene.
Protein type: Oncoprotein; Apoptosis; Cytoskeletal
Chromosomal Location of Human Ortholog: 10q21
Cellular Component: cytoskeleton; cytoplasm
Molecular Function: protein binding; structural constituent of cytoskeleton; SH3 domain binding
Disease: Thyroid Carcinoma, Papillary
Research Articles on CCDC6
1. the loss of CCDC6 could aid the spermatogonial cells to be part of a pro-survival pathway that helps to evade the toxic effects of endogenous oxidants and contributes to testicular neoplastic growth.
Precautions
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Disclaimer
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