Product Name
CNTNAP2, cDNA Clone
Full Product Name
CNTNAP2 cDNA Clone
Product Gene Name
CNTNAP2 cdna clone
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
ATGCAGGCGG CTCCGCGCGC CGGCTGCGGG GCAGCGCTCC TGCTGTGGAT TGTCAGCAGC TGCCTCTGCA GAGCCTGGAC GGCTCCCTCC ACGTCCCAAA AATGTGATGA GCCACTTGTC TCTGGACTCC CCCATGTGGC TTTCAGCAGC TCCTCCTCCA TCTCTGGTAG CTATTCTCCC GGCTATGCCA AGATAAACAA GAGAGGAGGT GCTGGGGGAT GGTCTCCATC AGACAGCGAC CATTATCAAT GGCTTCAGGT TGACTTTGGC AATCGGAAGC AGATCAGTGC CATTGCAACC CAAGGAAGGT ATAGCAGCTC AGATTGGGTG ACCCAATACC GGATGCTCTA CAGCGACACA GGGAGAAACT GGAAACCCTA TCATCAAGAT GGGAATATCT GGGCATTTCC CGGAAACATT AACTCTGACG GTGTGGTCCG GCACGAATTA CAGCATCCGA TTATTGCCCG CTATGTGCGC ATAGTGCCTC TGGATTGGAA TGGAGAAGGT CGCATTGGAC TCAGAATTGA AGTTTATGGC TGTTCTTACT GGGCTGATGT TATCAACTTT GATGGCCATG TTGTATTACC ATATAGATTC AGAAACAAGA AGATGAAAAC ACTGAAAGAT GTCATTGCCT TGAACTTTAA GACGTCTGAA AGTGAAGGAG TAATCCTGCA CGGAGAAGGA CAGCAAGGAG ATTACATTAC CTTGGAACTG AAAAAAGCCA AGCTGGTCCT CAGTTTAAAC TTAGGAAGCA ACCAGCTTGG CCCCATATAT GGCCACACAT CAGTGATGAC AGGAAGTTTG CTGGATGACC ACCACTGGCA CTCTGTGGTC ATTGAGCGCC AGGGGCGGAG CATTAACCTC ACTCTGGACA GGAGCATGCA GCACTTCCGT ACCAATGGAG AGTTTGACTA CCTGGACTTG GACTATGAGA TAACCTTTGG AGGCATCCCT TTCTCTGGCA AGCCCAGCTC CAGCAGTAGA AAGAATTTCA AAGGCTGCAT GGAAAGCATC AACTACAATG GCGTCAACAT TACTGATCTT GCCAGAAGGA AGAAATTAGA GCCCTCAAAT GTGGGAAATT TGAGCTTTTC TTGTGTGGAA CCCTATACGG TGCCTGTCTT TTTCAACGCT ACAAGTTACC TGGAGGTGCC CGGACGGCTT AACCAGGACC TGTTCTCAGT CAGTTTCCAG TTTAGGACAT GGAACCCCAA TGGTCTCCTG GTCTTCAGTC ACTTTGCGGA TAATTTGGGC AATGTGGAGA TTGACCTCAC TGAAAGCAAA GTGGGTGTTC ACATCAACAT CACACAGACC AAGATGAGCC AAATCGATAT TTCCTCAGGT TCTGGGTTGA ATGATGGACA GTGGCACGAG GTTCGCTTCC TAGCCAAGGA AAATTTTGCT ATTCTCACCA TCGATGGAGA TGAAGCATCA GCAGTTCGAA CTAATAGTCC CCTTCAAGTT AAAACTGGCG AGAAGTACTT TTTTGGAGGT TTTCTGAACC AGATGAATAA CTCAAGTCAC TCTGTCCTTC AGCCTTCATT CCAAGGATGC ATGCAGCTCA TTCAAGTGGA CGATCAACTT GTAAATTTAT ACGAAGTGGC ACAAAGGAAG CCGGGAAGTT TCGCGAATGT CAGCATTGAC ATGTGTGCAA TCATAGACAG ATGTGTGCCC AATCACTGTG AGCATGGTGG AAAGTGCTCG CAAACATGGG ACAGCTTCAA ATGCACTTGT GATGAGACAG GATACAGTGG GGCCACCTGC CACAACTCTA TCTACGAGCC TTCCTGTGAA GCCTACAAAC ACCTAGGACA GACATCAAAT TATTACTGGA TAGATCCTGA TGGCAGCGGA CCTCTGGGGC CTCTGAAAGT TTACTGCAAC ATGACAGAGG ACAAAGTGTG GACCATAGTG TCTCATGACT TGCAGATGCA GACGCCTGTG GTCGGCTACA ACCCAGAAAA ATACTCAGTG ACACAGCTCG TTTACAGCGC CTCCATGGAC CAGATAAGTG CCATCACTGA CAGTGCCGAG TACTGCGAGC AGTATGTCTC CTATTTCTGC AAGATGTCAA GATTGTTGAA CACCCCAGAT GGAAGCCCTT ACACTTGGTG GGTTGGCAAA GCCAACGAGA AGCACTACTA CTGGGGAGGC TCTGGGCCTG GAATCCAGAA ATGTGCCTGC GGCATCGAAC GCAACTGCAC AGATCCCAAG TACTACTGTA ACTGCGACGC GGACTACAAG CAATGGAGGA AGGATGCTGG TTTCTTATCA TACAAAGATC ACCTGCCAGT GAGCCAAGTG GTGGTTGGAG ATACTGACCG TCAAGGCTCA GAAGCCAAAT TGAGCGTAGG TCCTCTGCGC TGCCAAGGAG ACAGGAATTA TTGGAATGCC GCCTCTTTCC CAAACCCATC CTCCTACCTG CACTTCTCTA CTTTCCAAGG GGAAACTAGC GCTGACATTT CTTTCTACTT CAAAACATTA ACCCCCTGGG GAGTGTTTCT TGAAAATATG GGAAAGGAAG ATTTCATCAA GCTGGAGCTG AAGTCTGCCA CAGAAGTGTC CTTTTCATTT GATGTGGGAA ATGGGCCAGT AGAGATTGTA GTGAGGTCAC CAACCCCTCT CAACGATGAC CAGTGGCACC GGGTCACTGC AGAGAGGAAT GTCAAGCAGG CCAGCCTACA GGTGGACCGG CTACCGCAGC AGATCCGCAA GGCCCCAACA GAAGGCCACA CCCGCCTGGA GCTCTACAGC CAGTTATTTG TGGGTGGTGC TGGGGGCCAG CAGGGCTTCC TGGGCTGCAT CCGCTCCTTG AGGATGAATG GGGTGACACT TGACCTGGAG GAAAGAGCAA AGGTCACATC TGGGTTCATA TCCGGATGCT CGGGCCATTG CACCAGCTAT GGAACAAACT GTGAAAATGG AGGCAAATGC CTAGAGAGAT ACCACGGTTA CTCCTGCGAT TGCTCTAATA CTGCATATGA TGGAACATTT TGCAACAAAG ATGTTGGTGC ATTTTTTGAA GAAGGGATGT GGCTACGATA TAACTTTCAG GCACCAGCAA CAAATGCCAG AGACTCCAGC AGCAGAGTAG ACAACGCTCC CGACCAGCAG AACTCCCACC CGGACCTGGC ACAGGAGGAG ATCCGCTTCA GCTTCAGCAC CACCAAGGCG CCCTGCATTC TCCTCTACAT CAGCTCCTTC ACCACAGACT TCTTGGCAGT CCTCGTCAAA CCCACTGGAA GCTTACAGAT TCGATACAAC CTGGGTGGCA CCCGAGAGCC ATACAATATT GACGTAGACC ACAGGAACAT GGCCAATGGA CAGCCCCACA GTGTCAACAT CACCCGCCAC GAGAAGACCA TCTTTCTCAA GCTCGATCAT TATCCTTCTG TGAGTTACCA TCTGCCAAGT TCATCCGACA CCCTCTTCAA TTCTCCCAAG TCGCTCTTTC TGGGAAAAGT TATAGAAACA GGGAAAATTG ACCAAGAGAT TCACAAATAC AACACCCCAG GATTCACTGG TTGCCTCTCC AGAGTCCAGT TCAACCAGAT CGCCCCTCTC AAGGCCGCCT TGAGGCAGAC AAACGCCTCG GCTCACGTCC ACATCCAGGG CGAGCTGGTG GAGTCCAACT GCGGGGCCTC GCCGCTGACC CTCTCCCCCA TGTCGTCCGC CACCGACCCC TGGCACCTGG ATCACCTGGA TTCAGCCAGT GCGGATTTTC CATATAATCC AGGACAAGGC CAAGCTATAA GAAATGGAGT CAACAGAAAC TCGGCTATCA TTGGAGGCGT CATTGCTGTG GTGATTTTCA CCATCCTGTG CACCCTGGTC TTCCTGATCC GGTACATGTT CCGCCACAAG GGCACCTACC ATACCAACGA AGCAAAGGGG GCGGAGTCGG CAGAGAGCGC GGACGCCGCC ATCATGAACA ACGACCCCAA CTTCACAGAG ACCATTGATG AAAGCAAAAA GGAATGGCTC ATTTGA
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CNTNAP2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CNTNAP2. It may not necessarily be applicable to this product.
NCBI Accession #
BC113373
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UniProt Secondary Accession #
Q14DG2; Q52LV1; Q5H9Q7; Q9UQ12; D3DWG2[Other Products]
UniProt Related Accession #
Q9UHC6[Other Products]
Molecular Weight
11,899 Da
NCBI Official Full Name
Homo sapiens contactin associated protein-like 2, mRNA
NCBI Official Synonym Full Names
contactin associated protein-like 2
NCBI Official Symbol
CNTNAP2??[Similar Products]
NCBI Official Synonym Symbols
CDFE; NRXN4; AUTS15; CASPR2; PTHSL1
??[Similar Products]
NCBI Protein Information
contactin-associated protein-like 2
UniProt Protein Name
Contactin-associated protein-like 2
UniProt Synonym Protein Names
Cell recognition molecule Caspr2
Protein Family
Contactin-associated protein
UniProt Gene Name
CNTNAP2??[Similar Products]
UniProt Synonym Gene Names
??[Similar Products]
UniProt Entry Name
CNTP2_HUMAN
NCBI Summary for CNTNAP2
This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ . This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.[provided by RefSeq, Mar 2010]
UniProt Comments for CNTNAP2
CNTNAP2: May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction. Associates with KCNA2. Predominantly expressed in nervous system. Belongs to the neurexin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q35
Cellular Component: axolemma; cell surface; early endosome; Golgi apparatus; membrane; voltage-gated potassium channel complex
Molecular Function: enzyme binding; protein binding
Biological Process: ***** behavior; brain development; cerebral cortex development; clustering of voltage-gated potassium channels; learning; limbic system development; neurite development; social behavior; striatum development; thalamus development; vocal learning
Disease: Autism, Susceptibility To, 15; Cortical Dysplasia-focal Epilepsy Syndrome
Research Articles on CNTNAP2
1. Structurally, CASPR2 is highly glycosylated and has an overall compact architecture. CASPR2 associates with micromolar affinity with CNTN1 but, under the same conditions, it does not interact with any of the other members of the contactin family.
Precautions
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Disclaimer
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