Product Name
C-Type Lectin Domain Family 4 (CLEC4C), Recombinant Protein
Popular Item
Full Product Name
Recombinant C-Type Lectin Domain Family 4, Member C (CLEC4C)
Product Gene Name
CLEC4C recombinant protein
[Similar Products]
Matching Pairs
Unconjugated
Antibody: C-Type Lectin Domain Family 4 (MBS2028250)
Immunogen: C-Type Lectin Domain Family 4 (MBS2029194)
Matching Pairs
APC-CY7 Conjugated Antibody: C-Type Lectin Domain Family 4, Member C (CLEC4C) (MBS2058504)
Immunogen: C-Type Lectin Domain Family 4 (MBS2029194)
Matching Pairs
PE Conjugated Antibody: C-Type Lectin Domain Family 4, Member C (CLEC4C) (MBS2058505)
Immunogen: C-Type Lectin Domain Family 4 (MBS2029194)
Matching Pairs
APC Conjugated Antibody: C-Type Lectin Domain Family 4, Member C (CLEC4C) (MBS2058506)
Immunogen: C-Type Lectin Domain Family 4 (MBS2029194)
Matching Pairs
Cy3 Conjugated Antibody: C-Type Lectin Domain Family 4, Member C (CLEC4C) (MBS2058507)
Immunogen: C-Type Lectin Domain Family 4 (MBS2029194)
Matching Pairs
FITC Conjugated Antibody: C-Type Lectin Domain Family 4, Member C (CLEC4C) (MBS2058508)
Immunogen: C-Type Lectin Domain Family 4 (MBS2029194)
Matching Pairs
HRP Conjugated Antibody: C-Type Lectin Domain Family 4, Member C (CLEC4C) (MBS2058509)
Immunogen: C-Type Lectin Domain Family 4 (MBS2029194)
Matching Pairs
Biotin Conjugated Antibody: C-Type Lectin Domain Family 4, Member C (CLEC4C) (MBS2093704)
Immunogen: C-Type Lectin Domain Family 4 (MBS2029194)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS2029194 Technical Datasheet
Technical Datasheet PDF
Sequence
The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below.
MGSSHHHHH H SSGLVPRGSH MASMTGGQQM GRGSEF- EEPQDR EKGLWWFQLK VWSMAVVSIL LLSVCFTVSS VVPHNFMYSK TVKRLSKLRE YQQYHPSLTC VMEGKDIEDW SCCPTPWTSF QSSCYFISTG MQSWTKSQKN CSVMGADLVV INTREEQDFI IQNLKRNSSY FLGLSDPGGR RHWQWVDQTP YNENVTFWHS GEPNNLDERC AII
Purity/Purification
> 97%
Concentration
Original Concentration: 200 ug/mL (lot specific)
Organism Species
Homo sapiens (Human)
Source
Prokaryotic expression
Subcellular Location
Membrane
Traits
Freeze-dried powder
Buffer
20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT,
0.01% SKL, 5% Trehalose.
Predicted isoelectric point
6.8
Predicted Molecular Mass
24.7kDa
Accurate Molecular Mass
25kDa as determined by SDS-PAGE reducing conditions.
Usage
Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Preparation and Storage
Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8oC for one month.
Aliquot and store at -80oC for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customera??s specifications, please inquire.
Other Notes
Small volumes of CLEC4C recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for CLEC4C recombinant protein
Positive Control; Immunogen; SDS-PAGE; WB.
(May be suitable for use in other assays to be determined by the end user.)
Sequence Information of CLEC4C recombinant protein
SDS-Page of CLEC4C recombinant protein
NCBI/Uniprot data below describe general gene information for CLEC4C. It may not necessarily be applicable to this product.
NCBI Accession #
NP_987099.1
[Other Products]
NCBI GenBank Nucleotide #
NM_203503.1
[Other Products]
UniProt Secondary Accession #
Q3T1C3; Q6UXS8; Q8WXX8; D3DUU3[Other Products]
UniProt Related Accession #
Q8WTT0[Other Products]
NCBI Official Full Name
C-type lectin domain family 4 member C isoform 2
NCBI Official Synonym Full Names
C-type lectin domain family 4, member C
NCBI Official Symbol
CLEC4C??[Similar Products]
NCBI Official Synonym Symbols
DLEC; HECL; BDCA2; CD303; CLECSF7; CLECSF11; PRO34150
??[Similar Products]
NCBI Protein Information
C-type lectin domain family 4 member C
UniProt Protein Name
C-type lectin domain family 4 member C
UniProt Synonym Protein Names
Blood dendritic cell antigen 2; BDCA-2; C-type lectin superfamily member 7; Dendritic lectin; CD_antigen: CD303
Protein Family
C-type lectin domain family
UniProt Gene Name
CLEC4C??[Similar Products]
UniProt Synonym Gene Names
BDCA2; CLECSF11; CLECSF7; DLEC; HECL; BDCA-2??[Similar Products]
UniProt Entry Name
CLC4C_HUMAN
NCBI Summary for CLEC4C
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CLEC4C
CLEC4C: Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein- tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 12p13.2-p12.3
Cellular Component: integral to membrane
Molecular Function: carbohydrate binding
Biological Process: innate immune response
Research Articles on CLEC4C
1. We show the crystal structures of a carbohydrate recognition domain (CRD) of human C-type lectin receptor blood dendritic cell antigen-2 (BDCA2).
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.