Product Name
DNA Ligase IV (LIG4), Polyclonal Antibody
Full Product Name
DNA Ligase IV Polyclonal Antibody
Product Gene Name
anti-LIG4 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P49917
Other Notes
Small volumes of anti-LIG4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for LIG4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001091738.1
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NCBI GenBank Nucleotide #
NM_001098268.1
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UniProt Primary Accession #
P49917
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UniProt Secondary Accession #
Q8IY66; Q8TEU5[Other Products]
UniProt Related Accession #
P49917[Other Products]
Molecular Weight
103,971 Da[Similar Products]
NCBI Official Full Name
DNA ligase 4 isoform 1
NCBI Official Synonym Full Names
DNA ligase 4
NCBI Official Symbol
LIG4??[Similar Products]
NCBI Official Synonym Symbols
LIG4S
??[Similar Products]
NCBI Protein Information
DNA ligase 4
UniProt Protein Name
DNA ligase 4
UniProt Synonym Protein Names
DNA ligase IV; Polydeoxyribonucleotide synthase [ATP] 4
Protein Family
DNA ligase
UniProt Gene Name
LIG4??[Similar Products]
NCBI Summary for LIG4
The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
UniProt Comments for LIG4
Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
Research Articles on LIG4
1. This study shown that both ligase IV and XRCC4 may act in concert to modulate the development of glioma.
Precautions
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Disclaimer
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