Product Name
CD41 LC 1 (ITGA2B), Blocking Peptide
Full Product Name
CD41 LC 1 Blocking Peptide
Product Synonym Names
GP2B; ITGAB; Integrin alpha-IIb; GPalpha IIb; GPIIb; Platelet membrane glycoprotein IIb; CD41
Product Gene Name
ITGA2B blocking peptide
[Similar Products]
CD41 LC 1 peptide (MBS8206119) is used for blocking the activity of CD41 LC 1 antibody (MBS8239023)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P08514
Species Reactivity
Human, Rat
Form/Format
Lyophilized powder
Quality Control
The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
Directions for Use
Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Other Notes
Small volumes of ITGA2B blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ITGA2B blocking peptide
The peptide is used to block Anti-CD41 LC 1 Antibody reactivity.
Applications Tested/Suitable for ITGA2B blocking peptide
Blocking (BL)
NCBI/Uniprot data below describe general gene information for ITGA2B. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000410.2
[Other Products]
NCBI GenBank Nucleotide #
NM_000419.3
[Other Products]
UniProt Primary Accession #
P08514
[Other Products]
UniProt Secondary Accession #
O95366; Q14443; Q17R67; B2RCY8[Other Products]
UniProt Related Accession #
P08514[Other Products]
Molecular Weight
103,218 Da
NCBI Official Full Name
integrin alpha-IIb preproprotein
NCBI Official Synonym Full Names
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
NCBI Official Symbol
ITGA2B??[Similar Products]
NCBI Official Synonym Symbols
GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16; PPP1R93
??[Similar Products]
NCBI Protein Information
integrin alpha-IIb
UniProt Protein Name
Integrin alpha-IIb
UniProt Synonym Protein Names
GPalpha IIb; GPIIb
UniProt Gene Name
ITGA2B??[Similar Products]
UniProt Synonym Gene Names
GP2B; ITGAB; GPIIb??[Similar Products]
UniProt Entry Name
ITA2B_HUMAN
NCBI Summary for ITGA2B
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
UniProt Comments for ITGA2B
ITGA2B: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. Belongs to the integrin alpha chain family. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q21.32
Cellular Component: platelet alpha granule membrane; focal adhesion; cell surface; integral to plasma membrane; plasma membrane; integrin complex; external side of plasma membrane
Molecular Function: identical protein binding; protein binding; extracellular matrix binding; metal ion binding
Biological Process: integrin-mediated signaling pathway; axon guidance; platelet activation; extracellular matrix organization and biogenesis; platelet degranulation; cell-matrix adhesion; positive regulation of leukocyte migration; blood coagulation; cell adhesion
Disease: Glanzmann Thrombasthenia; Bleeding Disorder, Platelet-type, 16
Research Articles on ITGA2B
1. post-treatment of peptides derived from the full-length tail or from the turn motif did not reverse aIIb and aV integrin activation.
Precautions
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Disclaimer
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