Product Name
Integrin alpha 2 (Itga2b), Monoclonal Antibody
Full Product Name
Rat Anti-Mouse Integrin alpha 2
Product Gene Name
anti-Itga2b antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9QUM0
Reconstitution
Reconstitute the antibody with 500 ul sterile PBS and the final concentration is 200 ug/ml.
Antibody Generation
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of Integrin a2 (also called CD49b).
Preparation and Storage
Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C.
Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-Itga2b antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Itga2b antibody
Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several
biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.
Applications Tested/Suitable for anti-Itga2b antibody
Western Blot (WB), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)
NCBI/Uniprot data below describe general gene information for Itga2b. It may not necessarily be applicable to this product.
NCBI Accession #
NP_034705.2
[Other Products]
NCBI GenBank Nucleotide #
NM_010575.2
[Other Products]
UniProt Primary Accession #
Q9QUM0
[Other Products]
UniProt Secondary Accession #
Q3U3R7; Q64229; Q9Z2M0[Other Products]
UniProt Related Accession #
Q9QUM0[Other Products]
Molecular Weight
112,678 Da[Similar Products]
NCBI Official Full Name
integrin alpha-IIb
NCBI Official Synonym Full Names
integrin alpha 2b
NCBI Official Symbol
Itga2b??[Similar Products]
NCBI Official Synonym Symbols
CD41; CD41B; GpIIb; AI172977; alphaIIb
??[Similar Products]
NCBI Protein Information
integrin alpha-IIb
UniProt Protein Name
Integrin alpha-IIb
UniProt Synonym Protein Names
GPalpha IIb; GPIIb
UniProt Gene Name
Itga2b??[Similar Products]
UniProt Synonym Gene Names
GPIIb??[Similar Products]
UniProt Comments for Itga2b
ITGA2B: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. Belongs to the integrin alpha chain family. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11 D|11 66.29 cM
Cellular Component: cell surface; external side of plasma membrane; focal adhesion
Molecular Function: extracellular matrix binding; identical protein binding
Biological Process: cell-matrix adhesion; integrin-mediated signaling pathway; positive regulation of leukocyte migration
Research Articles on Itga2b
1. ITGA2b expression increases in response to immunization, raising the possibility that heterogeneous ITGA2b levels reflect variation in exposure to activation signals.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
