Polyclonal Integrin alpha 2b; Anti-Integrin alpha 2b; HPA3; ITGA2B; CD41B; GPalpha IIb; Integrin alpha b-2; GPIIb; GP2B; CD41; GTA; Integrin alpha b 2; Integrin alpha 2b; platelet membrane glycoprotein IIb

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Integrin alpha 2b antibody was purified by antigen-affinity chromatography

Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative.

0.7 mg/ml (lot specific)

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Small volumes of anti-ITGA2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Affinity purified Rabbit polyclonal Integrin alpha 2b antibody

Cell Biology; Purified Polyclonal Antibodies

Western Blot (WB)

WB: 1:500-1:3000

Immunohistochemical staining using Integrin alpha 2b antibody
Immunohistochemical staining of paraffin-embedded PC13 xenograft using Integrin alpha 2b antibody at a dilution of 1:500

Western blot analysis using Integrin alpha 2b antibody
Western blot analysis of 30 ug of whole cell lysate (A: A549) using a 7.5 % SDS PAGE gel and Integrin alpha 2b antibody at a dilution of 1:500

113 kDa[Similar Products]

integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)

integrin alpha-IIb

Integrin alpha-IIb

GP2B; ITGAB; GPIIb??[Similar Products]

ITA2B_HUMAN

ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]

ITGA2B: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. Belongs to the integrin alpha chain family. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: platelet alpha granule membrane; cell surface; focal adhesion; integral to plasma membrane; plasma membrane; integrin complex; external side of plasma membrane

Molecular Function: identical protein binding; protein binding; extracellular matrix binding; metal ion binding

Biological Process: integrin-mediated signaling pathway; platelet activation; axon guidance; extracellular matrix organization and biogenesis; platelet degranulation; positive regulation of leukocyte migration; cell-matrix adhesion; cell adhesion; blood coagulation

Disease: Glanzmann Thrombasthenia; Bleeding Disorder, Platelet-type, 16

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