Product Name
BAPX1 (NKX3-2), Blocking Peptide
Full Product Name
BAPX1 Peptide
Product Synonym Names
SMMD; BAPX1; NKX3B; NKX3.2; Bagpipe homeobox protein homolog 1; NK3 homeobox 2
Product Gene Name
NKX3-2 blocking peptide
[Similar Products]
BAPX1 peptide (MBS151808) is used for blocking the activity of BAPX1 antibody (MBS151381)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P78367
Concentration
200 ug/mL (lot specific)
Buffer
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Location
19 amino acid peptide near the center of human BAPX1.
Preparation and Storage
Store BAPX1 peptide at -20 degree C, stable for one year.
Other Notes
Small volumes of NKX3-2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for NKX3-2 blocking peptide
Blocking (BL)
Application Notes for NKX3-2 blocking peptide
BAPX1 peptide is used for blocking the activity of BAPX1 antibody.
Western Blot (WB) of NKX3-2 blocking peptide
Western blot analysis of BAPX1 in human brain tissue lysate with BAPX1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
NCBI/Uniprot data below describe general gene information for NKX3-2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001180
[Other Products]
NCBI GenBank Nucleotide #
NM_001189.3
[Other Products]
UniProt Primary Accession #
P78367
[Other Products]
UniProt Secondary Accession #
Q2M2I7[Other Products]
UniProt Related Accession #
P78367[Other Products]
Molecular Weight
34,814 Da
NCBI Official Full Name
homeobox protein Nkx-3.2
NCBI Official Synonym Full Names
NK3 homeobox 2
NCBI Official Symbol
NKX3-2??[Similar Products]
NCBI Official Synonym Symbols
SMMD; BAPX1; NKX3B; NKX3.2
??[Similar Products]
NCBI Protein Information
homeobox protein Nkx-3.2; homeobox protein NK-3 homolog B; bagpipe homeobox protein homolog 1
UniProt Protein Name
Homeobox protein Nkx-3.2
UniProt Synonym Protein Names
Bagpipe homeobox protein homolog 1; Homeobox protein NK-3 homolog B
Protein Family
Homeobox protein
UniProt Gene Name
NKX3-2??[Similar Products]
UniProt Synonym Gene Names
BAPX1; NKX3B??[Similar Products]
UniProt Entry Name
NKX32_HUMAN
NCBI Summary for NKX3-2
This gene encodes a member of the NK family of homeobox-containing proteins. The encoded protein may play a role in skeletal development. [provided by RefSeq, Jul 2008]
UniProt Comments for NKX3-2
NKX3-2: Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus. Defects in NKX3-2 are the cause of spondylo- megaepiphyseal-metaphyseal dysplasia (SMMD). It is a skeletal dysplasia characterized by disproportionate short stature with a short and stiff neck and trunk, relatively long limbs that may show flexion contractures of the distal joints, delayed and impaired ossification of the vertebral bodies, the presence of large epiphysea ossification centers and wide growth plates in the long tubular bones and numerous pseudoepiphyses of the short tubular bones in hands and feet. Belongs to the NK-3 homeobox family.
Protein type: Transcription factor; Cell development/differentiation; DNA-binding
Chromosomal Location of Human Ortholog: 4p16.3
Cellular Component: nucleus
Biological Process: transcription from RNA polymerase II promoter; spleen development; organ formation; skeletal morphogenesis; embryonic skeletal development; negative regulation of chondrocyte differentiation; pancreas development; negative regulation of transcription from RNA polymerase II promoter; middle ear morphogenesis; determination of left/right symmetry; skeletal development; negative regulation of apoptosis
Disease: Spondylo-megaepiphyseal-metaphyseal Dysplasia
Research Articles on NKX3-2
1. Ihh-induced Nkx3.2 degradation requires Wnt5a, which is capable of triggering Nkx3.2 degradation
Precautions
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Disclaimer
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